PMID- 29786040
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20220317
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 131
IP  - 11
DP  - 2018 Jun 5
TI  - Human Leukocyte Antigen-A Allele Distribution in Nasopharyngeal Carcinoma 
      Patients Showing Anti-Melanoma-Associated Antigen A or Synovial Sarcoma X-2 T 
      Cell Response in Blood.
PG  - 1289-1295
LID - 10.4103/0366-6999.232791 [doi]
AB  - BACKGROUND: Development of innovative immunotherapy is imperative to improve the 
      poor survival of the nasopharyngeal carcinoma (NPC) patients. In this study, we 
      evaluated the T cell response to melanoma-associated antigen (MAGE)-A1, MAGE-A3, 
      or synovial sarcoma X-2 (SSX-2) in the peripheral blood of treatment-naive NPC 
      patients. The relationship of responses among the three proteins and the human 
      leukocyte antigen (HLA)-A types were analyzed to provide evidence of designing 
      novel therapy. METHODS: Sixty-one NPC patients admitted into the Tumor Hospital 
      affiliated to the Xinjiang Medical University between March 2015 and July 2016 
      were enrolled. Mononuclear cells were isolated from the peripheral blood before 
      any treatment. HLA-A alleles were typed with Sanger sequence-based typing 
      technique. The T cell response to the MAGE-A1, MAGE-A3, or SSX-2 was evaluated 
      with the Enzyme-Linked ImmunoSpot assay. Mann-Whitney U-test was used to compare 
      the T cell responses from different groups. Spearman's rank correlation was used 
      to analyze the relationship of T cell responses. RESULTS: HLA-A*02:01, A*02:07, 
      and A*24:02 were the three most frequent alleles (18.9%, 12.3%, and 11.5%, 
      respectively) among the 22 detected alleles. 31.1%, 19.7%, and 16.4% of the 
      patients displayed MAGE-A1, MAGE-A3, or SSX-2-specific T cell response, 
      respectively. The magnitudes of response to the three proteins were 32.5, 38.0, 
      and 28.7 SFC/10(6) peripheral blood mononuclear cells, respectively. The T cell 
      response against the three proteins correlated with each other to different 
      extent. The percentage of A*02:01 and A*24:02 carriers were significantly higher 
      in patients responding to any of the three proteins compared to the 
      nonresponders. CONCLUSION: MAGE-A1, MAGE-A3, or SSX-2-specific T cell responses 
      were detectable in a subgroup of NPC patients, the frequency and magnitude of 
      which were correlated.
FAU - Fan, Pei-Wen
AU  - Fan PW
AD  - Xinjiang Key Laboratory of Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Huang, Li
AU  - Huang L
AD  - Department of Radiation Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Chang, Xue-Mei
AU  - Chang XM
AD  - Xinjiang Key Laboratory of Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Feng, Ya-Ning
AU  - Feng YN
AD  - Xinjiang Key Laboratory of Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University, Urumqi, Xinjiang 830000, China.
FAU - Yao, Xuan
AU  - Yao X
AD  - CAMS Oxford Center for Translation Immunology, Chinese Academy of Medical Science 
      Oxford Institute, Nuffield Department of Medicine; MRC Human Immunology Unit, 
      Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, 
      UK.
FAU - Peng, Yan-Chun
AU  - Peng YC
AD  - CAMS Oxford Center for Translation Immunology, Chinese Academy of Medical Science 
      Oxford Institute, Nuffield Department of Medicine; MRC Human Immunology Unit, 
      Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, 
      UK.
FAU - Dong, Tao
AU  - Dong T
AD  - CAMS Oxford Center for Translation Immunology, Chinese Academy of Medical Science 
      Oxford Institute, Nuffield Department of Medicine; MRC Human Immunology Unit, 
      Weatherall Institute of Molecular Medicine, Oxford University, Oxford OX3 9DS, 
      UK.
FAU - Wang, Ruo-Zheng
AU  - Wang RZ
AD  - Xinjiang Key Laboratory of Oncology, The Affiliated Tumor Hospital of Xinjiang 
      Medical University; Department of Radiation Oncology, The Affiliated Tumor 
      Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830000, China.
LA  - eng
GR  - G0600520/MRC_/Medical Research Council/United Kingdom
GR  - G1001046/MRC_/Medical Research Council/United Kingdom
GR  - MC_UU_00008/11/MRC_/Medical Research Council/United Kingdom
GR  - MR/L018942/1/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA-A Antigens)
RN  - 0 (MAGEA3 protein, human)
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Antigens, Neoplasm/*immunology/metabolism
MH  - Carcinoma/*immunology/metabolism
MH  - Female
MH  - HLA-A Antigens/*metabolism
MH  - Humans
MH  - Leukocytes, Mononuclear/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*immunology/metabolism
MH  - Neoplasm Proteins/metabolism
MH  - Sarcoma, Synovial/*immunology/metabolism
MH  - Young Adult
PMC - PMC5987498
OTO - NOTNLM
OT  - Human Leukocyte Antigen-A
OT  - Melanoma-Associated Antigen-A
OT  - Nasopharyngeal Carcinoma
OT  - Synovial Sarcoma X-2
OT  - T Cell Response
COIS- There are no conflicts of interest
EDAT- 2018/05/23 06:00
MHDA- 2018/10/03 06:00
PMCR- 2018/06/05
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [entrez]
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/06/05 00:00 [pmc-release]
AID - ChinMedJ_2018_131_11_1289_232791 [pii]
AID - CMJ-131-1289 [pii]
AID - 10.4103/0366-6999.232791 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2018 Jun 5;131(11):1289-1295. doi: 10.4103/0366-6999.232791.