PMID- 29786738
OWN - NLM
STAT- MEDLINE
DCOM- 20190122
LR  - 20190122
IS  - 2040-3372 (Electronic)
IS  - 2040-3364 (Linking)
VI  - 10
IP  - 21
DP  - 2018 May 31
TI  - Design and mechanistic study of a novel gold nanocluster-based drug delivery 
      system.
PG  - 10166-10172
LID - 10.1039/c8nr02189a [doi]
AB  - Chemically-triggered drug delivery systems (DDSs) have been extensively studied 
      as they do not require specialized equipment to deliver the drug and can deeply 
      penetrate human tissue. However, their syntheses are complicated and they tend to 
      be cytotoxic, which restricts their clinical utility. In this work, the 
      self-regulated drug loading and release capabilities of peptide-protected gold 
      nanoclusters (Pep-Au NCs) are investigated using vancomycin (Van) as the model 
      drug. Gold nanoclusters (Au NCs) coated with a custom-designed pentapeptide are 
      synthesized as drug delivery nanocarriers and loaded with Van - a spontaneous 
      process reliant on the specific binding between Van and the custom-designed 
      peptide. The Van-loaded Au NCs show comparable antimicrobial activity with Van on 
      its own, and the number of Van released by the Pep-Au NCs is found to be 
      proportional to the amount of bacteria present. The controlled nature of the Van 
      release is very encouraging, and predominantly due to the stronger binding 
      affinity of Van with bacteria than that with Au NCs. In addition, these 
      fluorescent Au NCs could also be used to construct temperature sensors, which 
      enable the in vitro and in vivo bioimaging.
FAU - Li, Qinzhen
AU  - Li Q
AD  - Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, 
      Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid 
      Functionalized Materials, Anhui University, Hefei, Anhui 230601, China. 
      yuhaizhu@ahu.edu.cn zmz@ahu.edu.cn.
FAU - Pan, Yiting
AU  - Pan Y
FAU - Chen, Tiankai
AU  - Chen T
FAU - Du, Yuanxin
AU  - Du Y
FAU - Ge, Honghua
AU  - Ge H
FAU - Zhang, Buchang
AU  - Zhang B
FAU - Xie, Jianping
AU  - Xie J
FAU - Yu, Haizhu
AU  - Yu H
FAU - Zhu, Manzhou
AU  - Zhu M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Nanoscale
JT  - Nanoscale
JID - 101525249
RN  - 0 (Peptides)
RN  - 6Q205EH1VU (Vancomycin)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - Cricetulus
MH  - *Drug Delivery Systems
MH  - *Gold
MH  - Humans
MH  - MCF-7 Cells
MH  - Male
MH  - Metal Nanoparticles/*chemistry
MH  - Mice, Nude
MH  - Microscopy, Confocal
MH  - Optical Imaging
MH  - Peptides/*chemistry
MH  - Vancomycin/administration & dosage
EDAT- 2018/05/23 06:00
MHDA- 2019/01/23 06:00
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2019/01/23 06:00 [medline]
PHST- 2018/05/23 06:00 [entrez]
AID - 10.1039/c8nr02189a [doi]
PST - ppublish
SO  - Nanoscale. 2018 May 31;10(21):10166-10172. doi: 10.1039/c8nr02189a.