PMID- 29787417
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Aug
TI  - Human leukocyte antigen mismatch and precision medicine in transplantation.
PG  - 500-505
LID - 10.1097/MOT.0000000000000540 [doi]
AB  - PURPOSE OF REVIEW: Pretransplant and posttransplant alloimmune risk assessment 
      needs to evolve towards a precision medicine model already used in other areas of 
      medicine. Although this has not been possible with traditional risk factors 
      available at the time of transplant, new methods of human leukocyte antigen (HLA) 
      molecular mismatch have generated hope that alloimmune risk assessment may be 
      precise enough for personalized treatment strategies. RECENT FINDINGS: This 
      review describes the various HLA molecular mismatch methods and some of the 
      recent publications for each method. These include studies that have evaluated 
      HLA molecular mismatch in the context of lung, pancreas and kidney transplant as 
      a correlate with short and long-term outcomes. The limitations of traditional 
      alloimmune risk assessment strategies are highlighted in the context of 
      individualized patient care. CONCLUSION: Recent studies that have evaluated HLA 
      molecular mismatch in the context of immunosuppression minimization are examples 
      of how more precise measurements of alloimmune risk can lead to novel insights 
      that may help personalize immunosuppression protocols.
FAU - Wiebe, Chris
AU  - Wiebe C
AD  - Department of Internal Medicine, Max Rady College of Medicine, University of 
      Manitoba.
AD  - Diagnostic Services of Manitoba.
FAU - Nickerson, Peter
AU  - Nickerson P
AD  - Department of Internal Medicine, Max Rady College of Medicine, University of 
      Manitoba.
AD  - Diagnostic Services of Manitoba.
AD  - Department of Immunology, Max Rady College of Medicine, University of Manitoba, 
      Winnipeg, Manitoba, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (HLA Antigens)
SB  - IM
MH  - HLA Antigens/*immunology
MH  - Histocompatibility
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Organ Transplantation/*methods
MH  - Precision Medicine/*methods
MH  - Risk Factors
MH  - Transplantation Immunology
EDAT- 2018/05/23 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/05/23 06:00
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/05/23 06:00 [entrez]
AID - 10.1097/MOT.0000000000000540 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2018 Aug;23(4):500-505. doi: 
      10.1097/MOT.0000000000000540.