PMID- 29787603 OWN - NLM STAT- MEDLINE DCOM- 20181126 LR - 20181126 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 13 IP - 5 DP - 2018 TI - Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness. PG - e0197682 LID - 10.1371/journal.pone.0197682 [doi] LID - e0197682 AB - BACKGROUND: Glaucoma is a neurodegenerative disease, leading to thinning of the retinal nerve fibre layer (RNFL). The exact influence of ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFL thickness (RNFLT) is unknown and was analysed in a subgroup of the Gutenberg Health Study (GHS). METHODS: Global peripapillary RNFLT was measured in 3224 eyes of 1973 subjects (49% female) using spectral-domain optical coherence tomography (SD-OCT). The association of age, sex, ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFLT was analysed using Pearson correlation coefficient and fitting a linear mixed model. RESULTS: In the univariable analysis highest correlations were found for axial length (r = -0.27), spherical equivalent (r = 0.24), and glaucoma (r = -0.15) (p<0.0001, respectively). Other significant correlations with RNFLT were found for age, sex, intraocular pressure, systemic hypertension and systolic blood pressure, previous eye surgery, cholesterol, homocysteine, history of coronary artery disease, history of myocardial infarction, apnoea, diabetes and alcohol intake, p<0.05, respectively. Body length, body weight, BMI, diastolic blood pressure, blood glucose, HbA1c, history of apoplexy, cognitive function, peripheral artery disease, tinnitus, migraine, nicotine intake, central corneal thickness, and pseudophakia were not significantly correlated with RNFLT. The regression model revealed a significant relationship between RNFLT and age in decades (p<0.02), spherical equivalent (p<0.0001), axial length (p<0.0001), glaucoma (p<0.0001), tinnitus (p = 0.04), apnoea (p = 0.047), homocysteine (p = 0.05) and alcohol intake >10g/d for women and >20g/d for men (p = 0.02). Glaucoma, apnoea, higher homocysteine, higher alcohol intake and higher axial length as well as age were related to decreased RNFLT while higher spherical equivalent or history for tinnitus were related to thicker RNFL. CONCLUSION: RNFLT is related to age, ocular parameters and lifestyle factors. Considering these parameters in normative databases could improve the evaluation of peripapillary RNFLT. It is necessary to evaluate if a reduction of alcohol intake as well as the therapy of apnea or high homocysteine levels could positively influence RNFLT. FAU - Lamparter, Julia AU - Lamparter J AUID- ORCID: 0000-0002-9947-4198 AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. AD - Augenzentrum Leinfelden-Echterdingen, Leinfelden-Echterdingen, Germany. FAU - Schmidtmann, Irene AU - Schmidtmann I AD - Institute for Medical Biometry, Epidemiology, and Informatics (IMBEI) of the University Medical Center Mainz, Mainz, Germany. FAU - Schuster, Alexander K AU - Schuster AK AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. FAU - Siouli, Angeliki AU - Siouli A AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. AD - Clinic for Ophthalmology, Klinikum Frankfurt Hochst, Frankfurt, Germany. FAU - Wasielica-Poslednik, Joanna AU - Wasielica-Poslednik J AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. FAU - Mirshahi, Alireza AU - Mirshahi A AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. AD - Dardenne Eye Hospital, Bonn, Germany. FAU - Hohn, Rene AU - Hohn R AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. AD - Department of Ophthalmology, Inselspital, University Hospital Bern, Bern, Switzerland. FAU - Unterrainer, Josef AU - Unterrainer J AD - Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. FAU - Wild, Philipp S AU - Wild PS AD - Preventive Cardiology and Preventive Medicine / Center for Cardiology, University Medical Center Mainz, Mainz, Germany. AD - Center for Thrombosis and Hemostasis (CTH), University Medical Center Mainz, Mainz, Germany. AD - German Center for Cardiovascular Research (DZHK), partner site Rhine-Main, Mainz, Germany. FAU - Binder, Harald AU - Binder H AD - Institute for Medical Biometry, Epidemiology, and Informatics (IMBEI) of the University Medical Center Mainz, Mainz, Germany. FAU - Lackner, Karl AU - Lackner K AD - Institute for Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany. FAU - Beutel, Manfred E AU - Beutel ME AD - Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Mainz, Mainz, Germany. FAU - Munzel, Thomas AU - Munzel T AD - Center for Cardiology I, University Medical Center Mainz, Mainz, Germany. FAU - Pfeiffer, Norbert AU - Pfeiffer N AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. FAU - Hoffmann, Esther M AU - Hoffmann EM AD - Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany. LA - eng PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20180522 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Axial Length, Eye/*diagnostic imaging MH - Female MH - Glaucoma/*diagnostic imaging MH - Humans MH - Life Style MH - Male MH - Middle Aged MH - Nerve Fibers MH - Prospective Studies MH - Regression Analysis MH - Retina/anatomy & histology/*diagnostic imaging MH - Sex Factors MH - Tomography, Optical Coherence PMC - PMC5963756 COIS- The Gutenberg Health Study received funding from Boehringer Ingelheim and PHILIPS Medical Systems. This analysis was supported by Novartis Pharma GmbH and Heidelberg Engineering. This does not alter our adherence to PLOS ONE policies on sharing data and materials. EDAT- 2018/05/23 06:00 MHDA- 2018/11/27 06:00 PMCR- 2018/05/22 CRDT- 2018/05/23 06:00 PHST- 2017/06/24 00:00 [received] PHST- 2018/05/07 00:00 [accepted] PHST- 2018/05/23 06:00 [entrez] PHST- 2018/05/23 06:00 [pubmed] PHST- 2018/11/27 06:00 [medline] PHST- 2018/05/22 00:00 [pmc-release] AID - PONE-D-17-24010 [pii] AID - 10.1371/journal.pone.0197682 [doi] PST - epublish SO - PLoS One. 2018 May 22;13(5):e0197682. doi: 10.1371/journal.pone.0197682. eCollection 2018.