PMID- 29787856
OWN - NLM
STAT- MEDLINE
DCOM- 20190806
LR  - 20190806
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 73
DP  - 2018 Oct
TI  - The association of disease activity, pro-inflammatory cytokines, and neurotrophic 
      factors with depression in patients with rheumatoid arthritis.
PG  - 274-281
LID - S0889-1591(18)30185-5 [pii]
LID - 10.1016/j.bbi.2018.05.012 [doi]
AB  - Inflammation and trophic factors (brain-derived neurotrophic factor [BDNF], 
      vascular endothelial growth factor, glial cell line-derived neurotrophic factor, 
      and insulin-like growth factor-1) are associated with depression in the general 
      population. Rheumatoid arthritis (RA) is a chronic representative inflammatory 
      autoimmune disease; however, the association of disease activity, 
      pro-inflammatory cytokines, and neurotrophic factors with depression has not been 
      sufficiently investigated. Therefore, we determined the prevalence of depression 
      and risk factors for depression and deterioration of depressive symptoms in RA 
      patients. In addition, we analyzed the association between disease activity, 
      pro-inflammatory cytokines, trophic factors, and depression in RA (N = 474). 
      Demographic and laboratory data were examined, and routine assessment of patient 
      index data 3 (RAPID 3) and disease activity score 28-joint count C-reactive 
      protein (DAS 28-CRP) was performed to assess disease activity of RA. Depression 
      was measured using the Korean version of the Beck Depression Inventory-second 
      edition (K-BDI II). A K-BDI score >/=18 was considered the cut-off for depression 
      in accordance with a previous validation study. The serum level of 
      pro-inflammatory cytokines and neurotrophic factors was assessed by enzyme-linked 
      immune sorbent assay. The prevalence of depression was 32.4% in patients with RA. 
      The severity of disease activity of RA (RAPID 3 score [OR 2.34; 95% confidence 
      interval, CI 1.22-4.51], DAS 28-CRP [>/=3.2] [OR 1.60, 95% CI 1.01-2.53]) and 
      severity of fatigue (OR 1.26 95% CI 1.15-1.38) were associated with depression 
      and deterioration of depressive symptoms in the multivariate analysis. Among the 
      components of RAPID 3 and DAS 28-CRP, patient assessment for global health and 
      abilities for daily performance were more related to depression. The level of 
      pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha) was not related to 
      depression. The level of BDNF was significantly lower in RA patients with 
      depression and was negatively correlated with K-BDI II score. Depression was 
      related with the level of fatigue, low expression of BDNF, and high RA disease 
      activity, which was associated with impaired ability to perform activities of 
      daily life. Strict control of fatigue and disease activity to improve one's 
      capacity to perform daily life activities would be important to regulate 
      depression. The level of BDNF might be one of the possible biomarkers to predict 
      or monitor depression in patients with RA.
CI  - Copyright (c) 2018. Published by Elsevier Inc.
FAU - Cheon, Yun-Hong
AU  - Cheon YH
AD  - Division of Rheumatology, Department of Internal Medicine, Gyeongsang National 
      University Hospital, Jinju, Republic of Korea.
FAU - Lee, Seung-Geun
AU  - Lee SG
AD  - Division of Rheumatology, Department of Internal Medicine, Pusan National 
      University School of Medicine, Pusan, Republic of Korea.
FAU - Kim, Mingyo
AU  - Kim M
AD  - Division of Rheumatology, Department of Internal Medicine, Gyeongsang National 
      University Hospital, Jinju, Republic of Korea.
FAU - Kim, Hyun-Ok
AU  - Kim HO
AD  - Division of Rheumatology, Department of Internal Medicine, Gyeongsang National 
      University Hospital, Jinju, Republic of Korea.
FAU - Sun Suh, Young
AU  - Sun Suh Y
AD  - Division of Rheumatology, Department of Internal Medicine, Gyeongsang National 
      University Hospital, Jinju, Republic of Korea.
FAU - Park, Ki-Soo
AU  - Park KS
AD  - Department of Preventive Medicine, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Kim, Rock Bum
AU  - Kim RB
AD  - Department of Preventive Medicine, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Yang, Hyun-Su
AU  - Yang HS
AD  - Department of Preventive Medicine, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea.
FAU - Kim, Ji-Min
AU  - Kim JM
AD  - Division of Rheumatology, Department of Internal Medicine, Keimyung University 
      School of Medicine, Daegu, Republic of Korea.
FAU - Son, Chang-Nam
AU  - Son CN
AD  - Division of Rheumatology, Department of Internal Medicine, Keimyung University 
      School of Medicine, Daegu, Republic of Korea.
FAU - Kyoung Park, Eun
AU  - Kyoung Park E
AD  - Division of Rheumatology, Department of Internal Medicine, Pusan National 
      University School of Medicine, Pusan, Republic of Korea.
FAU - Kim, Sang-Hyon
AU  - Kim SH
AD  - Division of Rheumatology, Department of Internal Medicine, Keimyung University 
      School of Medicine, Daegu, Republic of Korea. Electronic address: 
      mdkim9111@dsmc.or.kr.
FAU - Lee, Sang-Il
AU  - Lee SI
AD  - Division of Rheumatology, Department of Internal Medicine, Gyeongsang National 
      University Hospital, Jinju, Republic of Korea; Division of Rheumatology, 
      Department of Internal Medicine, Gyeongsang National University School of 
      Medicine, Jinju, Republic of Korea. Electronic address: goldgu@gnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180519
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
MH  - Aged
MH  - Arthritis, Rheumatoid/immunology/physiopathology/*psychology
MH  - Biomarkers
MH  - Brain-Derived Neurotrophic Factor/analysis/blood
MH  - C-Reactive Protein/analysis
MH  - Cross-Sectional Studies
MH  - Cytokines/analysis/blood
MH  - Depression/epidemiology/immunology/*physiopathology
MH  - Depressive Disorder/epidemiology
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - Interleukin-1beta/analysis/blood
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factors/metabolism
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/analysis/blood
MH  - Vascular Endothelial Growth Factor A/analysis/blood
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Depression
OT  - Disease activity
OT  - K-BDI II score
OT  - Rheumatoid arthritis
EDAT- 2018/05/23 06:00
MHDA- 2019/08/07 06:00
CRDT- 2018/05/23 06:00
PHST- 2018/01/16 00:00 [received]
PHST- 2018/04/27 00:00 [revised]
PHST- 2018/05/14 00:00 [accepted]
PHST- 2018/05/23 06:00 [pubmed]
PHST- 2019/08/07 06:00 [medline]
PHST- 2018/05/23 06:00 [entrez]
AID - S0889-1591(18)30185-5 [pii]
AID - 10.1016/j.bbi.2018.05.012 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2018 Oct;73:274-281. doi: 10.1016/j.bbi.2018.05.012. Epub 2018 
      May 19.