PMID- 29788841
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20181022
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 33
IP  - 1_suppl
DP  - 2018 May
TI  - Heparin-induced thrombocytopenia complicating extracorporeal membrane oxygenation 
      support in pediatric patients: review of the literature and alternative 
      anticoagulants.
PG  - 7-17
LID - 10.1177/0267659118766723 [doi]
AB  - Heparin-induced thrombocytopenia (HIT) is a prothrombotic, immune-mediated 
      complication of unfractionated heparin (UFH) and low molecular weight heparin 
      therapy. HIT is characterized by moderate thrombocytopenia 5-10 days after 
      initial heparin exposure, detection of platelet-activating anti-platelet factor 
      4/heparin antibodies and an increased risk of venous and arterial thrombosis. 
      Extracorporeal membrane oxygenation (ECMO) is a form of mechanical circulatory 
      support used in critically ill patients with respiratory or cardiac failure. 
      Systemic anticoagulation is used to alleviate the thrombotic complications that 
      may occur when blood is exposed to artificial surfaces within the ECMO circuit. 
      Therefore, when HIT complicates patients on ECMO support, it is associated with a 
      high thrombotic morbidity and mortality. The following article reviews the 
      current knowledge in pediatric HIT, especially in ECMO patients, and the 
      alternative anticoagulation options in the presence of HIT.
FAU - Pollak, Uri
AU  - Pollak U
AUID- ORCID: 0000-0002-4575-3888
AD  - 1 Pediatric Cardiac Intensive Care Unit, The Edmond J Safra International 
      Congenital Heart Center; The Edmond and Lily Safra Children's Hospital; The Chaim 
      Sheba Medical Center, Tel Hashomer, Israel.
AD  - 2 Pediatric Cardiology, The Edmond J Safra International Congenital Heart Center; 
      The Edmond and Lily Safra Children's Hospital; The Chaim Sheba Medical Center, 
      Tel Hashomer, Israel.
AD  - 3 ECMO service, The Edmond J Safra International Congenital Heart Center; The 
      Edmond and Lily Safra Children's Hospital; The Chaim Sheba Medical Center, Tel 
      Hashomer, Israel.
AD  - 4 The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants/*adverse effects
MH  - Extracorporeal Membrane Oxygenation/*adverse effects/methods
MH  - Heparin/*adverse effects
MH  - Humans
MH  - Thrombocytopenia/*chemically induced
OTO - NOTNLM
OT  - Alternative anticoagulants
OT  - Direct factor-Xa inhibitors
OT  - Direct oral anticoagulants
OT  - Direct thrombin inhibitors
OT  - Extracorporeal membrane oxygenation
OT  - Heparin-induced thrombocytopenia
EDAT- 2018/05/24 06:00
MHDA- 2018/10/23 06:00
CRDT- 2018/05/24 06:00
PHST- 2018/05/24 06:00 [entrez]
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
AID - 10.1177/0267659118766723 [doi]
PST - ppublish
SO  - Perfusion. 2018 May;33(1_suppl):7-17. doi: 10.1177/0267659118766723.