PMID- 29788843
OWN - NLM
STAT- MEDLINE
DCOM- 20181022
LR  - 20190501
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Print)
IS  - 0267-6591 (Linking)
VI  - 33
IP  - 1_suppl
DP  - 2018 May
TI  - Effect of pump type on outcomes in neonates with congenital diaphragmatic hernia 
      requiring ECMO.
PG  - 71-79
LID - 10.1177/0267659118766729 [doi]
AB  - PURPOSE: With the exception of neonatal respiratory failure, most centers are now 
      using centrifugal over roller-type pumps for the delivery of extracorporeal 
      membrane oxygenation (ECMO). Evidence supporting the use of centrifugal pumps 
      specifically in infants with congenital diaphragmatic hernia (CDH) remains 
      lacking. We hypothesized that the use of centrifugal pumps in infants with CDH 
      would not affect mortality or rates of severe neurologic injury (SNI). METHODS: 
      Infants with CDH were identified within the ELSO registry (2000-2016). Patients 
      were then divided into those undergoing ECMO with rollertype pumps or centrifugal 
      pumps. Patients were matched based on propensity score (PS) for the ECMO pump 
      type based on pre-ECMO covariates. This was done for all infants and separately 
      for each ECMO mode, venovenous (VV) and venoarterial (VA) ECMO. RESULTS: We 
      identified 4,367 infants who were treated with either roller or centrifugal pumps 
      from 2000-2016. There was no difference in mortality or SNI between the two pump 
      types in any of the groups (all infants, VA-ECMO infants, VV-ECMO infants). 
      However, there was at least a six-fold increase in the odds of hemolysis for 
      centrifugal pumps in all groups: all infants (odds ratio [OR] 6.99, p<0.001), 
      VA-ECMO infants (OR 8.11, p<0.001 and VV-ECMO infants (OR 9.66, p<0.001). 
      CONCLUSION: For neonates with CDH requiring ECMO, there is no survival advantage 
      or difference in severe neurologic injury between those receiving roller or 
      centrifugal pump ECMO. However, there is a significant increase in red blood cell 
      hemolysis associated with centrifugal ECMO support.
FAU - Delaplain, Patrick T
AU  - Delaplain PT
AD  - 1 Department of Surgery, University of California, Irvine Medical Center, Irvine, 
      CA, USA.
AD  - 2 Department of Pediatric Surgery, Children's Hospital Los Angeles, University of 
      Southern California, Los Angeles, CA, USA.
FAU - Zhang, Lishi
AU  - Zhang L
AD  - 3 Biostatistics, Institute for Clinical and Translational Science, University of 
      California, Irvine, CA, USA.
FAU - Nguyen, Danh V
AU  - Nguyen DV
AD  - 4 Department of Medicine, Institute for Clinical and Translational Science, 
      University of California, Irvine, CA, USA.
FAU - Ashrafi, Amir H
AU  - Ashrafi AH
AD  - 5 Division of Neonatology, Children's Hospital of Orange County, Orange, CA, USA.
FAU - Yu, Peter T
AU  - Yu PT
AD  - 1 Department of Surgery, University of California, Irvine Medical Center, Irvine, 
      CA, USA.
AD  - 6 Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, 
      CA, USA.
FAU - Di Nardo, Matteo
AU  - Di Nardo M
AD  - 7 Pediatric Intensive Care Unit, Children's Hospital Bambino Gesu, IRCCS, Rome, 
      Italy.
FAU - Chen, Yanjun
AU  - Chen Y
AD  - 3 Biostatistics, Institute for Clinical and Translational Science, University of 
      California, Irvine, CA, USA.
FAU - Starr, Joanne
AU  - Starr J
AD  - 8 Division of Cardiothoracic Surgery, Children's Hospital of Orange County, 
      Orange, CA, USA.
FAU - Ford, Henri R
AU  - Ford HR
AD  - 2 Department of Pediatric Surgery, Children's Hospital Los Angeles, University of 
      Southern California, Los Angeles, CA, USA.
FAU - Guner, Yigit S
AU  - Guner YS
AD  - 1 Department of Surgery, University of California, Irvine Medical Center, Irvine, 
      CA, USA.
AD  - 6 Division of Pediatric Surgery, Children's Hospital of Orange County, Orange, 
      CA, USA.
LA  - eng
GR  - UL1 TR001414/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
SB  - IM
MH  - Extracorporeal Membrane Oxygenation/*adverse effects/methods
MH  - Female
MH  - Hemolysis
MH  - Hernias, Diaphragmatic, Congenital/pathology/*therapy
MH  - Humans
MH  - Infant, Newborn
MH  - Male
MH  - Treatment Outcome
PMC - PMC6294336
MID - NIHMS996054
OTO - NOTNLM
OT  - centrifugal pump
OT  - congenital diaphragmatic hernia (CDH)
OT  - extracorporeal membrane oxygenation (EMCO)
OT  - hemolysis
OT  - roller pump
EDAT- 2018/05/24 06:00
MHDA- 2018/10/23 06:00
PMCR- 2019/05/01
CRDT- 2018/05/24 06:00
PHST- 2018/05/24 06:00 [entrez]
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2018/10/23 06:00 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - 10.1177/0267659118766729 [doi]
PST - ppublish
SO  - Perfusion. 2018 May;33(1_suppl):71-79. doi: 10.1177/0267659118766729.