PMID- 29789149 OWN - NLM STAT- MEDLINE DCOM- 20200117 LR - 20200117 IS - 1872-9142 (Electronic) IS - 0161-5890 (Linking) VI - 115 DP - 2019 Nov TI - The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells. PG - 31-38 LID - S0161-5890(18)30146-9 [pii] LID - 10.1016/j.molimm.2018.05.001 [doi] AB - Major Histocompatibility Complex-I (MHC-I) molecules can be divided into class Ia and class Ib, with three distinct class Ib families found in the mouse. These families are designated as Q, T and M and are largely unexplored in terms of their immunological function. Among the class Ib MHC, H2-T23 (Qa-1b) has been a significant target for Natural Killer (NK) cell research, owing to its homology with the human class Ib human leukocyte antigen (HLA)-E. However, recent data has indicated that members of the Q and M family of class Ib MHC also play a critical role in the development and regulation NK cells. Here we discuss the recent advances in the control of NK cells by murine class Ib MHC as a means to stimulate further exploration of these molecules. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Goodall, Katharine J AU - Goodall KJ AD - Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia. FAU - Nguyen, Angela AU - Nguyen A AD - Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia. FAU - Sullivan, Lucy C AU - Sullivan LC AD - Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia. FAU - Andrews, Daniel M AU - Andrews DM AD - Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia. Electronic address: dan.andrews@monash.edu. LA - eng PT - Journal Article PT - Review DEP - 20180520 PL - England TA - Mol Immunol JT - Molecular immunology JID - 7905289 RN - 0 (HLA Antigens) RN - 0 (Histocompatibility Antigens Class I) SB - IM MH - Animals MH - HLA Antigens/immunology MH - Histocompatibility Antigens Class I/*immunology MH - Humans MH - Killer Cells, Natural/*immunology OTO - NOTNLM OT - Major histocompatibility complex OT - Natural killer cell EDAT- 2018/05/24 06:00 MHDA- 2020/01/18 06:00 CRDT- 2018/05/24 06:00 PHST- 2017/11/06 00:00 [received] PHST- 2018/04/21 00:00 [revised] PHST- 2018/05/02 00:00 [accepted] PHST- 2018/05/24 06:00 [pubmed] PHST- 2020/01/18 06:00 [medline] PHST- 2018/05/24 06:00 [entrez] AID - S0161-5890(18)30146-9 [pii] AID - 10.1016/j.molimm.2018.05.001 [doi] PST - ppublish SO - Mol Immunol. 2019 Nov;115:31-38. doi: 10.1016/j.molimm.2018.05.001. Epub 2018 May 20.