PMID- 29789464
OWN - NLM
STAT- MEDLINE
DCOM- 20180918
LR  - 20211204
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 5
DP  - 2018 May 22
TI  - Role of mTOR Complexes in Neurogenesis.
LID - 10.3390/ijms19051544 [doi]
LID - 1544
AB  - Dysregulation of neural stem cells (NSCs) is associated with several 
      neurodevelopmental disorders, including epilepsy and autism spectrum disorder. 
      The mammalian target of rapamycin (mTOR) integrates the intracellular signals to 
      control cell growth, nutrient metabolism, and protein translation. mTOR regulates 
      many functions in the development of the brain, such as proliferation, 
      differentiation, migration, and dendrite formation. In addition, mTOR is 
      important in synaptic formation and plasticity. Abnormalities in mTOR activity is 
      linked with severe deficits in nervous system development, including tumors, 
      autism, and seizures. Dissecting the wide-ranging roles of mTOR activity during 
      critical periods in development will greatly expand our understanding of 
      neurogenesis.
FAU - LiCausi, Francesca
AU  - LiCausi F
AD  - Biology Program, School of Natural Sciences and Mathematics, Stockton University, 
      Galloway, NJ 08205, USA. nams@stockton.edu.
FAU - Hartman, Nathaniel W
AU  - Hartman NW
AD  - Biology Program, School of Natural Sciences and Mathematics, Stockton University, 
      Galloway, NJ 08205, USA. nathaniel.hartman@stockton.edu.
LA  - eng
GR  - R15 NS092026/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180522
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cell Cycle
MH  - Humans
MH  - *Neurogenesis
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
PMC - PMC5983636
OTO - NOTNLM
OT  - dendrite
OT  - differentiation
OT  - mTOR
OT  - neural stem cells
OT  - synapse formation
COIS- The authors declare no conflict of interest.
EDAT- 2018/05/24 06:00
MHDA- 2018/09/19 06:00
PMCR- 2018/05/01
CRDT- 2018/05/24 06:00
PHST- 2018/04/30 00:00 [received]
PHST- 2018/05/13 00:00 [revised]
PHST- 2018/05/16 00:00 [accepted]
PHST- 2018/05/24 06:00 [entrez]
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2018/09/19 06:00 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - ijms19051544 [pii]
AID - ijms-19-01544 [pii]
AID - 10.3390/ijms19051544 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 May 22;19(5):1544. doi: 10.3390/ijms19051544.