PMID- 29789706
OWN - NLM
STAT- MEDLINE
DCOM- 20190422
LR  - 20190422
IS  - 1476-5624 (Electronic)
IS  - 1362-4393 (Linking)
VI  - 56
IP  - 10
DP  - 2018 Oct
TI  - Short-segment transverse myelitis lesions in a cohort of Latin American patients 
      with neuromyelitis optica spectrum disorders.
PG  - 949-954
LID - 10.1038/s41393-018-0143-6 [doi]
AB  - STUDY DESIGN: Multicenter retrospective study. OBJECTIVES: The aim was to 
      determine the frequency and magnetic resonance imaging (MRI) features of 
      short-segment transverse myelitis (STM) in patients with neuromyelitis optica 
      spectrum disorders (NMOSD) during a myelitis attack. SETTING: Latin American 
      diagnostic centres (Neuroimmunology Unit). A multicenter study from Argentina, 
      Brazil and Venezuela was performed. METHODS: Seventy-six patients with NMOSD were 
      included. We analyzed 346 attacks and reviewed spinal cord MRIs performed within 
      30 days from spinal attack onset. Sagittal and axial characteristics on cervical 
      and thoracic MRI (1.5 tesla) were observed. Demographics, clinical, serological, 
      and disability data were collected. RESULTS: Among the 76 patients with NMOSD, 
      isolated STM was observed in 8% (n = 6), multisegmental lesions (longitudinally 
      extensive transverse myelitis (LETM) + STM) in 28% (n = 21; 13 had at least one 
      STM), LETM in 42% (n = 32), and normal spinal MRI in 22% (n = 17). However, 
      isolated STM was increased by 10% in patients with NMOSD with spinal lesions (6 
      out of 59) with mean attacks of 2.5 (+/-0.83) and last follow-up expanded 
      disability status scale (EDSS) of 3.1 (+/-2.63). Positive aquaporin 4 antibodies 
      (AQP4-ab) were found in 50%. Upper-cervical lesion was most frequently observed 
      (5 out of 6). Myelitis was preceded by ON in all isolated patients with STM. Only 
      one had a positive gadolinium lesion and none of these had asymptomatic spinal 
      cord lesion. CONCLUSION: Isolated STM does not exclude NMOSD diagnosis. 
      Therefore, APQ4-ab testing could be useful during a myelitis attack with STM.
FAU - Carnero Contentti, Edgar
AU  - Carnero Contentti E
AD  - Neuroimmunology Unit, Department of Neuroscience Hospital Aleman, Buenos Aires, 
      Argentina. junior.carnero@hotmail.com.
FAU - Daccach Marques, Vanessa
AU  - Daccach Marques V
AD  - Departamento de Neurociencias e Ciencias do Comportamento, Hospital das Clinicas 
      da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo, Sao 
      Pablo, Brazil.
FAU - Soto de Castillo, Ibis
AU  - Soto de Castillo I
AD  - Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela.
FAU - Tkachuk, Veronica
AU  - Tkachuk V
AD  - Neurology Department, Hospital Jose de San Martin, Buenos Aires, Argentina.
FAU - Antunes Barreira, Amilton
AU  - Antunes Barreira A
AD  - Departamento de Neurociencias e Ciencias do Comportamento, Hospital das Clinicas 
      da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo, Sao 
      Pablo, Brazil.
FAU - Armas, Elizabeth
AU  - Armas E
AD  - Neurology Department, Hospital Universitario de Caracas, Caracas, Venezuela.
FAU - Chiganer, Edson
AU  - Chiganer E
AD  - Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
FAU - de Aquino Cruz, Camila
AU  - de Aquino Cruz C
AD  - Departamento de Neurociencias e Ciencias do Comportamento, Hospital das Clinicas 
      da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo, Sao 
      Pablo, Brazil.
FAU - Di Pace, Jose Luis
AU  - Di Pace JL
AD  - Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
FAU - Hryb, Javier Pablo
AU  - Hryb JP
AD  - Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
FAU - Lavigne Moreira, Carolina
AU  - Lavigne Moreira C
AD  - Departamento de Neurociencias e Ciencias do Comportamento, Hospital das Clinicas 
      da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo, Sao 
      Pablo, Brazil.
FAU - Lessa, Carmen
AU  - Lessa C
AD  - Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
FAU - Molina, Omaira
AU  - Molina O
AD  - Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela.
FAU - Perassolo, Monica
AU  - Perassolo M
AD  - Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina.
FAU - Soto, Arnoldo
AU  - Soto A
AD  - Neurology Department, Hospital Universitario de Caracas, Caracas, Venezuela.
FAU - Caride, Alejandro
AU  - Caride A
AD  - Neuroimmunology Unit, Department of Neuroscience Hospital Aleman, Buenos Aires, 
      Argentina.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20180522
PL  - England
TA  - Spinal Cord
JT  - Spinal cord
JID - 9609749
SB  - IM
MH  - Adult
MH  - Cervical Vertebrae
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Neuromyelitis Optica/*diagnostic imaging
MH  - Retrospective Studies
MH  - Spinal Cord/*diagnostic imaging
MH  - Thoracic Vertebrae
EDAT- 2018/05/24 06:00
MHDA- 2019/04/23 06:00
CRDT- 2018/05/24 06:00
PHST- 2018/01/23 00:00 [received]
PHST- 2018/03/21 00:00 [accepted]
PHST- 2018/03/19 00:00 [revised]
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2019/04/23 06:00 [medline]
PHST- 2018/05/24 06:00 [entrez]
AID - 10.1038/s41393-018-0143-6 [pii]
AID - 10.1038/s41393-018-0143-6 [doi]
PST - ppublish
SO  - Spinal Cord. 2018 Oct;56(10):949-954. doi: 10.1038/s41393-018-0143-6. Epub 2018 
      May 22.