PMID- 29790041 OWN - NLM STAT- MEDLINE DCOM- 20190610 LR - 20221207 IS - 1862-3514 (Electronic) IS - 1862-3522 (Print) VI - 13 IP - 1 DP - 2018 May 22 TI - Volumetric bone mineral density (vBMD), bone structure, and structural geometry among rural South Indian, US Caucasian, and Afro-Caribbean older men. PG - 60 LID - 10.1007/s11657-018-0473-1 [doi] LID - 60 AB - Peripheral quantitative computed tomography (pQCT) provides biomechanical estimates of bone strength. Rural South Indian men have reduced biomechanical indices of bone strength compared to US Caucasian and Afro-Caribbean men. This suggests an underlying higher risk of osteoporotic fractures and greater future fracture burden among the rural South Indian men. INTRODUCTION: Geographical and racial comparisons of bone mineral density (BMD) have largely focused on DXA measures of areal BMD. In contrast, peripheral quantitative computed tomography (pQCT) measures volumetric BMD (vBMD), bone structural geometry and provides estimates of biomechanical strength. To further understand potential geographical and racial differences in skeletal health, we compared pQCT measures among US Caucasian, Afro-Caribbean, and rural South Indian men. METHODS: We studied men aged >/= 60 years enrolled in the Mobility and Independent Living among Elders Study (MILES) in rural south India (N = 245), Osteoporotic Fractures in Men Study (MrOS) in the US (N = 1148), and the Tobago Bone Health Study (N = 828). RESULTS: The BMI (kg/m(2)) of rural South Indian men (21.6) was significantly lower compared to the US Caucasians (28) and Afro-Caribbean men (26.9). Adjusting for age, height, body weight, and grip strength; rural South Indian men compared to US Caucasians had significantly lower trabecular vBMD [- 1.3 to - 1.5 standard deviation (SD)], cortical thickness [- 0.8 to - 1.2 SD]; significantly higher endosteal circumference [0.5 to 0.8 SD]; but similar cortical vBMD. Afro-Caribbean men compared to US Caucasians had similar trabecular vBMD but significantly higher cortical vBMD [0.9 to 1.2 SD], SSIp [0.2 to 1.4 SD], and tibial endosteal circumference [1 SD], CONCLUSIONS: In comparison to US Caucasians, rural South Indian men have reduced bone strength (lower trabecular vBMD) and Afro-Caribbean men have greater bone strength (higher cortical vBMD). These results suggest an underlying higher risk of osteoporotic fractures and greater future fracture burden among rural South Indian men. FAU - Jammy, Guru Rajesh AU - Jammy GR AD - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA. guj7@pitt.edu. FAU - Boudreau, Robert M AU - Boudreau RM AD - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA. FAU - Singh, Tushar AU - Singh T AD - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA. FAU - Sharma, Pawan Kumar AU - Sharma PK AD - SHARE INDIA - MediCiti Institute of Medical Sciences, Ghanpur Village, Medchal District, Telangana, India. FAU - Ensrud, Kristine AU - Ensrud K AD - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, 55455, USA. AD - Department of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA. AD - Center for Chronic Disease Outcomes Research, VA Health Care System, Minneapolis, MN, 55455, USA. FAU - Zmuda, Joseph M AU - Zmuda JM AD - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA. FAU - Reddy, P S AU - Reddy PS AD - SHARE INDIA - MediCiti Institute of Medical Sciences, Ghanpur Village, Medchal District, Telangana, India. FAU - Newman, Anne B AU - Newman AB AD - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA. FAU - Cauley, Jane A AU - Cauley JA AD - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15260, USA. LA - eng GR - UL1 TR000128/TR/NCATS NIH HHS/United States GR - U01 AG042124/AG/NIA NIH HHS/United States GR - R01 CA084950/CA/NCI NIH HHS/United States GR - U01 AG042145/AG/NIA NIH HHS/United States GR - D43 TW009078/TW/FIC NIH HHS/United States GR - U01 AG042168/AG/NIA NIH HHS/United States GR - U01 AG042140/AG/NIA NIH HHS/United States GR - R01 AR049747/AR/NIAMS NIH HHS/United States GR - U01 AG027810/AG/NIA NIH HHS/United States GR - U01 AG042143/AG/NIA NIH HHS/United States GR - U01 AG042139/AG/NIA NIH HHS/United States GR - U01 AR066160/AR/NIAMS NIH HHS/United States PT - Journal Article PT - Multicenter Study PT - Research Support, N.I.H., Extramural DEP - 20180522 PL - England TA - Arch Osteoporos JT - Archives of osteoporosis JID - 101318988 SB - IM MH - Aged MH - *Asian People MH - Bone Density/*physiology MH - Caribbean Region/epidemiology MH - Female MH - Humans MH - India/epidemiology MH - Male MH - Middle Aged MH - Osteoporotic Fractures/*diagnosis/ethnology/metabolism MH - Prevalence MH - Tibia/*diagnostic imaging MH - Tomography, X-Ray Computed/*methods MH - United States/epidemiology MH - *White People PMC - PMC5978815 OTO - NOTNLM OT - Epidemiology OT - India OT - Men OT - Osteoporosis OT - Race/ethnicity OT - Volumetric BMD OT - pQCT COIS- None. EDAT- 2018/05/24 06:00 MHDA- 2019/06/14 06:00 PMCR- 2018/05/22 CRDT- 2018/05/24 06:00 PHST- 2017/07/14 00:00 [received] PHST- 2018/05/02 00:00 [accepted] PHST- 2018/05/24 06:00 [entrez] PHST- 2018/05/24 06:00 [pubmed] PHST- 2019/06/14 06:00 [medline] PHST- 2018/05/22 00:00 [pmc-release] AID - 10.1007/s11657-018-0473-1 [pii] AID - 473 [pii] AID - 10.1007/s11657-018-0473-1 [doi] PST - epublish SO - Arch Osteoporos. 2018 May 22;13(1):60. doi: 10.1007/s11657-018-0473-1.