PMID- 29790209
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 1540-8183 (Electronic)
IS  - 0896-4327 (Linking)
VI  - 31
IP  - 5
DP  - 2018 Oct
TI  - Subclinical leaflet thrombosis following transcatheter aortic valve replacement.
PG  - 640-647
LID - 10.1111/joic.12521 [doi]
AB  - Since the inception of transcatheter aortic valve replacement (TAVR), there have 
      been significant reductions in complications due to improvements of transcatheter 
      heart valve (THV) designs and technologies. Given expanding TAVR applications, 
      reducing complications further and better understanding THV durability has become 
      a focus within the structural heart space. Recently, dedicated cardiac computed 
      tomographic angiography (CTA) performed at 1 month post-TAVR has identified 
      subclinical leaflet thrombosis (SLT), with rates as high as 40%. From the SLT 
      imaging hallmarks of hypoattenuated leaflet thickening (HALT) to hypoattenuation 
      affecting motion (HAM), a postulated timeline of THV thrombosis advancing to 
      clinical symptoms can be recognized. This review article focuses on leaflet 
      thrombosis particularly following TAVR explaining the spectrum of this disease 
      process, its diagnosis, current treatment options, and future directions in the 
      field.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Kanjanauthai, Somsupha
AU  - Kanjanauthai S
AUID- ORCID: 0000-0001-6837-4170
AD  - Lenox Hill Heart and Lung, New York, New York.
FAU - Pirelli, Luigi
AU  - Pirelli L
AD  - Lenox Hill Heart and Lung, New York, New York.
FAU - Nalluri, Nikhil
AU  - Nalluri N
AUID- ORCID: 0000-0002-4563-1127
AD  - Staten Island University Hospital, Valve and Structural Heart Center, New York, 
      New York.
FAU - Kliger, Chad A
AU  - Kliger CA
AD  - Lenox Hill Heart and Lung, New York, New York.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180523
PL  - United States
TA  - J Interv Cardiol
JT  - Journal of interventional cardiology
JID - 8907826
SB  - IM
MH  - *Aortic Valve/diagnostic imaging/surgery
MH  - Aortic Valve Stenosis/surgery
MH  - Computed Tomography Angiography/*methods
MH  - Heart Valve Prosthesis/*adverse effects
MH  - Humans
MH  - *Postoperative Complications/diagnostic imaging/etiology/prevention & control
MH  - *Thrombosis/diagnostic imaging/etiology/prevention & control
MH  - Transcatheter Aortic Valve Replacement/*adverse effects/methods
OTO - NOTNLM
OT  - hypoattenuated leaflet thickening
OT  - hypoattenuation affecting motion
OT  - leaflet thrombosis
OT  - reduced leaflet motion
OT  - transcatheter aortic valve replacement
OT  - transcatheter heart valve thrombosis
EDAT- 2018/05/24 06:00
MHDA- 2018/11/27 06:00
CRDT- 2018/05/24 06:00
PHST- 2018/01/10 00:00 [received]
PHST- 2018/04/22 00:00 [revised]
PHST- 2018/04/26 00:00 [accepted]
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/05/24 06:00 [entrez]
AID - 10.1111/joic.12521 [doi]
PST - ppublish
SO  - J Interv Cardiol. 2018 Oct;31(5):640-647. doi: 10.1111/joic.12521. Epub 2018 May 
      23.