PMID- 29791320
OWN - NLM
STAT- MEDLINE
DCOM- 20190329
LR  - 20220129
IS  - 1361-6579 (Electronic)
IS  - 0967-3334 (Linking)
VI  - 39
IP  - 6
DP  - 2018 Jun 19
TI  - Modelling the cerebral haemodynamic response in the physiological range of 
      PaCO(2).
PG  - 065001
LID - 10.1088/1361-6579/aac76b [doi]
AB  - OBJECTIVE: Arterial CO(2) (PaCO(2)) has a strong effect on cerebral blood flow 
      (CBF), but its influence on CBF regulatory mechanisms and circulatory systemic 
      variables has not been fully described over the entire physiological range of 
      PaCO(2). APPROACH: CBF velocity (CBFV, transcranial Doppler), blood pressure (BP, 
      Finometer) and end-tidal CO(2) (EtCO(2), capnography) were measured in 45 healthy 
      volunteers (19 male, mean age 37.5 years, range 21-71) at baseline, and in 
      response to hypo- (-5 mm Hg and  -10 mm Hg below baseline) and hypercapnia (5% 
      and 8% CO(2)), applied in random order. MAIN RESULTS: CBFV, cerebral dynamic 
      autoregulation index (ARI), heart rate (HR), arterial blood pressure (ABP), 
      critical closing pressure (CrCP) and resistance-area product (RAP) changed 
      significantly (all p  <  0.0001) for hypo- and hyper-capnia. These parameters 
      were shown to follow a logistic curve relationship representing a 'dose-response' 
      curve for the effects of PaCO(2) on the cerebral and systemic circulations. The 
      four logistic model parameters describing each 'dose-response' curve were 
      specific to each of the modelled variables (ANOVA p  <  0.0001). SIGNIFICANCE: 
      The ability to model the CBFV, ARI, HR, ABP, CrCP and RAP dependency of PaCO(2) 
      over its entire physiological range is a powerful tool for physiological and 
      clinical studies, including the need to perform adjustments in disease 
      populations with differing values of baseline PaCO(2).
FAU - Minhas, J S
AU  - Minhas JS
AD  - Department of Cardiovascular Sciences, Cerebral Haemodynamics in Ageing and 
      Stroke Medicine (CHIASM) Research Group, University of Leicester, Leicester, 
      United Kingdom.
FAU - Panerai, R B
AU  - Panerai RB
FAU - Robinson, T G
AU  - Robinson TG
LA  - eng
GR  - RTF97/0117/DMT_/The Dunhill Medical Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180619
PL  - England
TA  - Physiol Meas
JT  - Physiological measurement
JID - 9306921
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arteries/*metabolism/physiology
MH  - Carbon Dioxide/*metabolism
MH  - *Cerebrovascular Circulation
MH  - Female
MH  - *Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Models, Biological
MH  - Young Adult
EDAT- 2018/05/24 06:00
MHDA- 2019/03/30 06:00
CRDT- 2018/05/24 06:00
PHST- 2018/05/24 06:00 [pubmed]
PHST- 2019/03/30 06:00 [medline]
PHST- 2018/05/24 06:00 [entrez]
AID - 10.1088/1361-6579/aac76b [doi]
PST - epublish
SO  - Physiol Meas. 2018 Jun 19;39(6):065001. doi: 10.1088/1361-6579/aac76b.