PMID- 29791504 OWN - NLM STAT- MEDLINE DCOM- 20181126 LR - 20181126 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 13 IP - 5 DP - 2018 TI - Periconceptional maternal dairy-rich dietary pattern is associated with prenatal cerebellar growth. PG - e0197901 LID - 10.1371/journal.pone.0197901 [doi] LID - e0197901 AB - BACKGROUND: Maternal nutrition during pregnancy has been related to intrauterine brain development and neurodevelopmental disabilities in adult life. We aim to investigate associations between periconceptional maternal dietary patterns and prenatal cerebellar growth from the first trimester onwards. MATERIALS AND METHODS: 126 women with singleton non-malformed pregnancies were enrolled before 8 weeks of gestation in the Rotterdam periconceptional cohort between 2013 and 2015. Periconceptional maternal dietary patterns were extracted from food frequency questionnaires and associated with blood biomarkers and micronutrient intakes. Serial two-dimensional and three-dimensional ultrasound scans were performed at 9, 11, 22, 26 and 32 weeks of gestation for transcerebellar diameter (TCD) measurement. Linear mixed models were estimated to investigate associations between periconceptional maternal dietary patterns and longitudinal TCD measurements as a function of gestational age. RESULTS: We performed a median of 4 scans per pregnancy, resulting in 570 total datasets. The success rate of TCD measurements was 87% (range 65-100%), depending on gestational age. The Mediterranean, Western, egg-rich and dairy-rich dietary patterns were extracted, explaining 37.2% of the overall variance of food intake in this population. The dairy-rich dietary pattern was positively associated with cerebellar growth trajectories (beta = 0.02 (95% CI: 0.01; 0.03) radicalmm, p = 0.01). Maternal strong adherence to this dietary pattern increased TCD measurements by 0.8 standard deviation scores (SDs) compared to weak adherence, reflected in increased TCD estimates of 0.44 mm at 9 weeks (+6.8%), 0.88 mm at 22 weeks (+3.6%), and 1.17 mm at 32 weeks (+2.8%). No significant associations were detected for the Mediterranean, Western and egg-rich dietary patterns. CONCLUSIONS: This study shows a positive association between periconceptional maternal adherence to a dairy-rich dietary pattern and human prenatal TCD measurements as a proxy of cerebellar growth. Next step is the investigation of the impact on neurodevelopmental outcomes in the offspring. FAU - Parisi, Francesca AU - Parisi F AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Rousian, Melek AU - Rousian M AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Koning, Irene V AU - Koning IV AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Willemsen, Sten P AU - Willemsen SP AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. AD - Department of Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - de Vries, Jeanne H M AU - de Vries JHM AD - Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. FAU - Steegers, Eric A P AU - Steegers EAP AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Steegers-Theunissen, Regine P M AU - Steegers-Theunissen RPM AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. AD - Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180523 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Cerebellum/diagnostic imaging/*drug effects/*embryology MH - Crown-Rump Length MH - *Dairy Products MH - *Diet MH - Female MH - *Fertilization MH - *Fetal Development MH - Humans MH - Middle Aged MH - *Mothers MH - Pregnancy MH - Pregnancy Trimester, First MH - Ultrasonography, Prenatal MH - Young Adult PMC - PMC5965865 COIS- The authors have declared that no competing interests exist. EDAT- 2018/05/24 06:00 MHDA- 2018/11/27 06:00 PMCR- 2018/05/23 CRDT- 2018/05/24 06:00 PHST- 2017/11/23 00:00 [received] PHST- 2018/05/10 00:00 [accepted] PHST- 2018/05/24 06:00 [entrez] PHST- 2018/05/24 06:00 [pubmed] PHST- 2018/11/27 06:00 [medline] PHST- 2018/05/23 00:00 [pmc-release] AID - PONE-D-17-41355 [pii] AID - 10.1371/journal.pone.0197901 [doi] PST - epublish SO - PLoS One. 2018 May 23;13(5):e0197901. doi: 10.1371/journal.pone.0197901. eCollection 2018.