PMID- 29792929
OWN - NLM
STAT- MEDLINE
DCOM- 20190227
LR  - 20190227
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 23
IP  - 10
DP  - 2018 Oct
TI  - Recent advances in intra-articular drug delivery systems for osteoarthritis 
      therapy.
PG  - 1761-1775
LID - S1359-6446(18)30046-1 [pii]
LID - 10.1016/j.drudis.2018.05.023 [doi]
AB  - Osteoarthritis (OA) is the most common degenerative disease of the joint. Despite 
      many reports and numerous clinical trials, OA is not entirely understood, and 
      there is no effective treatment available for this disease. To satisfy this unmet 
      medical need, drug delivery systems (DDSs) containing disease-modifying OA drugs 
      (DMOADs) for intra-articular (IA) administration are required to improve the 
      health of OA patients. DDSs should provide controlled and/or sustained drug 
      release, enabling long-term treatment with a reduced number of injections. This 
      paper reviews the role and interaction among different tissues involved in OA and 
      summarizes recent clinical trials and research on DDSs, focusing on 
      small-molecule delivery. To achieve an ideal treatment, various key criteria have 
      been identified to design and develop an IA DDS matching the clinical needs.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Maudens, Pierre
AU  - Maudens P
AD  - School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 
      1211 Geneva, Switzerland. Electronic address: pierre.maudens@unige.ch.
FAU - Jordan, Olivier
AU  - Jordan O
AD  - School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 
      1211 Geneva, Switzerland.
FAU - Allemann, Eric
AU  - Allemann E
AD  - School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 
      1211 Geneva, Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180521
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Delayed-Action Preparations)
SB  - IM
MH  - Animals
MH  - Antirheumatic Agents/*administration & dosage
MH  - Delayed-Action Preparations
MH  - *Drug Delivery Systems
MH  - Drug Design
MH  - Drug Development/methods
MH  - Humans
MH  - Injections, Intra-Articular
MH  - Osteoarthritis/*drug therapy/physiopathology
EDAT- 2018/05/25 06:00
MHDA- 2019/02/28 06:00
CRDT- 2018/05/25 06:00
PHST- 2018/03/01 00:00 [received]
PHST- 2018/04/17 00:00 [revised]
PHST- 2018/05/16 00:00 [accepted]
PHST- 2018/05/25 06:00 [pubmed]
PHST- 2019/02/28 06:00 [medline]
PHST- 2018/05/25 06:00 [entrez]
AID - S1359-6446(18)30046-1 [pii]
AID - 10.1016/j.drudis.2018.05.023 [doi]
PST - ppublish
SO  - Drug Discov Today. 2018 Oct;23(10):1761-1775. doi: 10.1016/j.drudis.2018.05.023. 
      Epub 2018 May 21.