PMID- 29792981 OWN - NLM STAT- MEDLINE DCOM- 20181024 LR - 20181024 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 118 DP - 2018 Aug TI - Probabilistic non-carcinogenic and carcinogenic risk assessments (Monte Carlo simulation method) of the measured acrylamide content in Tah-dig using QuEChERS extraction and UHPLC-MS/MS. PG - 361-370 LID - S0278-6915(18)30338-7 [pii] LID - 10.1016/j.fct.2018.05.038 [doi] AB - A modified "Quick, Easy, Cheap, Effective, Rugged, and Safe" QuEChERS in combination with Ultra-High Performance Liquid Chromatography/tandem mass spectrometry (UHPLC-MS/MS) method was optimized for the determination of acrylamide content in different types of tah-dig (rice, bread, and potato). Also, the non-carcinogenic and carcinogenic risks (target hazard quotient (THQ) and incremental lifetime cancer risk (ILCR)) due to ingestion of acrylamide via tah-dig in the adults and children were assessed by Monte Carlo simulation (MCS) method. The recoveries of acrylamide at five concentration levels (n = 3) ranged from 83.82% to 106.41%. The repeatability of the proposed method was demonstrated with RSD% in the range of 11.3-20%. In addition, the limits of detection and quantification were reported as 5 ngg(-1) and 15 ngg(-1), respectively. The mean levels of the acrylamide contents in rice tah-dig, bread tah-dig, and potato tah-dig were measured as 24.65 ngg(-1), 39.48 ngg(-1), and 714.11 ngg(-1), respectively. The highest acrylamide content was determined in potato tah-dig (2100 ngg(-1)) and the lowest acrylamide in rice tah-dig ( rice tah-dig > bread tah-dig. There is a considerable non-carcinogenic risk for the children due to ingestion potato tah-dig (THQ > 1). Additionally, the significant carcinogenic risk for the Iranian adults and children due to consumption of rice, bread, and potato tah-dig (ILCR > 1.00E-5) was observed. CI - Copyright (c) 2018 Elsevier Ltd. All rights reserved. FAU - Shahrbabki, Parvin Eslami AU - Shahrbabki PE AD - Department of Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Hajimohammadi, Bahador AU - Hajimohammadi B AD - Research Center for Food Hygiene and Safety, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. FAU - Shoeibi, Shahram AU - Shoeibi S AD - Food and Drug Control Laboratory Reference Center (FDCLRC), Food and Drug Organization (FDO), Ministry of Health and Medical Education, Tehran, Iran; Food and Drug Laboratory Research Center (FDLRC), Food and Drug Organization (FDO), Ministry of Health and Medical Education, Tehran, Iran. FAU - Elmi, Mehdi AU - Elmi M AD - Food and Drug Control Laboratory Reference Center (FDCLRC), Food and Drug Organization (FDO), Ministry of Health and Medical Education, Tehran, Iran; Food and Drug Laboratory Research Center (FDLRC), Food and Drug Organization (FDO), Ministry of Health and Medical Education, Tehran, Iran. FAU - Yousefzadeh, Arash AU - Yousefzadeh A AD - Iran University of Medical Sciences, Tehran, Iran. FAU - Conti, Gea Oliveri AU - Conti GO AD - Department of Medical, Surgical Sciences, and Advanced Technologies "G.F. Ingrassia," University of Catania, Italy. FAU - Ferrante, Margherita AU - Ferrante M AD - Department of Medical, Surgical Sciences, and Advanced Technologies "G.F. Ingrassia," University of Catania, Italy. FAU - Amirahmadi, Maryam AU - Amirahmadi M AD - Food and Drug Control Laboratory Reference Center (FDCLRC), Food and Drug Organization (FDO), Ministry of Health and Medical Education, Tehran, Iran; Food and Drug Laboratory Research Center (FDLRC), Food and Drug Organization (FDO), Ministry of Health and Medical Education, Tehran, Iran. Electronic address: maryamamir2001@yahoo.com. FAU - Fakhri, Yadolah AU - Fakhri Y AD - Department of Environmental Health Engineering, Student Research Committee, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mousavi Khaneghah, Amin AU - Mousavi Khaneghah A AD - Department of Food Science, Faculty of Food Engineering, State University of Campinas (UNICAMP), Monteiro Lobato, 80, Caixa Postal: 6121, CEP: 13083-862, Campinas, Sao Paulo, Brazil. Electronic address: mousavi.amin@gmail.com. LA - eng PT - Journal Article DEP - 20180521 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 0 (Carcinogens) RN - 20R035KLCI (Acrylamide) SB - IM MH - Acrylamide/analysis/*toxicity MH - Bread/*analysis MH - Carcinogens/analysis/*toxicity MH - Chromatography, High Pressure Liquid/*methods MH - Limit of Detection MH - *Monte Carlo Method MH - Oryza/*chemistry MH - *Probability MH - Reproducibility of Results MH - Risk Assessment MH - Solanum tuberosum/*chemistry MH - Tandem Mass Spectrometry/*methods OTO - NOTNLM OT - Acrylamide OT - Modified QuEChERS OT - Probabilistic risk OT - Risk assessment OT - Tah-dig OT - UHPLC-MS/MS EDAT- 2018/05/25 06:00 MHDA- 2018/10/26 06:00 CRDT- 2018/05/25 06:00 PHST- 2018/02/20 00:00 [received] PHST- 2018/04/07 00:00 [revised] PHST- 2018/05/16 00:00 [accepted] PHST- 2018/05/25 06:00 [pubmed] PHST- 2018/10/26 06:00 [medline] PHST- 2018/05/25 06:00 [entrez] AID - S0278-6915(18)30338-7 [pii] AID - 10.1016/j.fct.2018.05.038 [doi] PST - ppublish SO - Food Chem Toxicol. 2018 Aug;118:361-370. doi: 10.1016/j.fct.2018.05.038. Epub 2018 May 21.