PMID- 29793265
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1744-828X (Electronic)
IS  - 1741-0541 (Linking)
VI  - 2
IP  - 3
DP  - 2005 Aug
TI  - HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: 
      implications for personalizing medicine.
PG  - 225-237
LID - 10.2217/17410541.2.3.225 [doi]
AB  - Preventing severe adverse drug reactions by identifying people at risk with a 
      simple genetic test is the goal of many pharmacogenomic studies. Stevens-Johnson 
      syndrome (SJS) and toxic epidermal necrolysis (TEN) are related, life-threatening 
      cutaneous adverse reactions, most often caused by medication. The overall 
      incidence and the commonly offending drugs vary among different ethnic 
      populations. Susceptibility to such idiosyncratic reactions is thought to be 
      genetically determined and immune mediated. Finding a strong genetic association 
      between a particular human leukocyte antigen (HLA)-B allele and the reaction to a 
      specific drug provides evidence that the pathogenesis of the severe cutaneous 
      adverse drug reactions involves major histocompatibility complex-restricted 
      presentation of a drug or its metabolites for T-cell activation. In the case of 
      carbamazepine-induced SJS/TEN, the tight association of the HLA-B*1502 allele 
      (sensitivity 100%, specificity 97% and odds ratio 2504) provides a plausible 
      basis for further development of such a test to identify individuals at risk of 
      developing this life-threatening condition.
FAU - Hung, Shuen-Iu
AU  - Hung SI
AD  - Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, 
      Nankang, Taipei, Taiwan. chen0010@ibms.sinica.edu.tw.
FAU - Chung, Wen-Hung
AU  - Chung WH
AD  - Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, 
      Nankang, Taipei, Taiwan. chen0010@ibms.sinica.edu.tw.
AD  - Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
FAU - Chen, Yuan-Tsong
AU  - Chen YT
AD  - Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, 
      Nankang, Taipei, Taiwan. chen0010@ibms.sinica.edu.tw.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Per Med
JT  - Personalized medicine
JID - 101238549
OTO - NOTNLM
OT  - Stevens-Johnson syndrome
OT  - adverse drug reaction
OT  - carbamazepine
OT  - human leukocyte antigen
OT  - personalized medicine
OT  - pharmacogenetics
OT  - preventive medicine
OT  - toxic epidermal necrolysis
EDAT- 2005/08/01 00:00
MHDA- 2005/08/01 00:01
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2005/08/01 00:00 [pubmed]
PHST- 2005/08/01 00:01 [medline]
AID - 10.2217/17410541.2.3.225 [doi]
PST - ppublish
SO  - Per Med. 2005 Aug;2(3):225-237. doi: 10.2217/17410541.2.3.225.