PMID- 29793748
OWN - NLM
STAT- MEDLINE
DCOM- 20190214
LR  - 20190215
IS  - 1471-4981 (Electronic)
IS  - 1471-4906 (Linking)
VI  - 39
IP  - 7
DP  - 2018 Jul
TI  - NK Cells Mediate a Crucial Graft-versus-Leukemia Effect in Haploidentical-HSCT to 
      Cure High-Risk Acute Leukemia.
PG  - 577-590
LID - S1471-4906(18)30086-3 [pii]
LID - 10.1016/j.it.2018.04.009 [doi]
AB  - Natural killer (NK) cells are involved in innate defenses against viruses and 
      tumors. Their function is finely tuned by activating and inhibitory receptors. 
      Among the latter, killer immunoglobulin-like receptors and CD94/NKG2A recognize 
      human leukocyte antigen (HLA) Class I molecules, allowing NK cells to 
      discriminate between normal and aberrant cells, as well as to recognize 
      allogeneic cells, because of their ability to sense HLA polymorphisms. This 
      latter phenomenon plays a key role in HLA-haploidentical hematopoietic stem cell 
      transplantation (haplo-HSCT) for high-risk acute leukemia patients transplanted 
      from an NK-alloreactive donor. Different haplo-HSCT settings have been developed, 
      either T depleted or T replete - the latter requiring graft-versus-host disease 
      prophylaxis. A novel graft manipulation, based on depletion of alphabeta T cells and B 
      cells, allows infusion of fully mature, including alloreactive, NK cells. The 
      excellent patient clinical outcome underscores the importance of these innate 
      cells in cancer therapy.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Locatelli, Franco
AU  - Locatelli F
AD  - IRCCS Ospedale Pediatrico Bambino Gesu, Dipartimento di Oncoematologia e Terapia 
      Cellulare e Genica, Roma, Italy; Universita degli Studi di Pavia, Dipartimento di 
      Scienze Pediatriche, Pavia, Italy.
FAU - Pende, Daniela
AU  - Pende D
AD  - IRCCS Ospedale Policlinico San Martino, Genova, Italy.
FAU - Falco, Michela
AU  - Falco M
AD  - IRCCS Istituto Giannina Gaslini, Dipartimento dei Laboratori di Ricerca, Genova, 
      Italy.
FAU - Della Chiesa, Mariella
AU  - Della Chiesa M
AD  - Universita degli Studi di Genova, Dipartimento di Medicina Sperimentale, Genova, 
      Italy; Centro di Eccellenza per la Ricerca Biomedica, Universita degli Studi di 
      Genova, Genova, Italy.
FAU - Moretta, Alessandro
AU  - Moretta A
AD  - Universita degli Studi di Genova, Dipartimento di Medicina Sperimentale, Genova, 
      Italy; Centro di Eccellenza per la Ricerca Biomedica, Universita degli Studi di 
      Genova, Genova, Italy.
FAU - Moretta, Lorenzo
AU  - Moretta L
AD  - IRCCS Ospedale Pediatrico Bambino Gesu, Area di Ricerca Immunologica, Roma, 
      Italy. Electronic address: lorenzo.moretta@opbg.net.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180521
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Graft vs Leukemia Effect/*immunology
MH  - HLA Antigens/immunology
MH  - Hematopoietic Stem Cell Transplantation/methods
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Leukemia/*immunology
EDAT- 2018/05/26 06:00
MHDA- 2019/02/15 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/02/05 00:00 [received]
PHST- 2018/04/20 00:00 [revised]
PHST- 2018/04/23 00:00 [accepted]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2019/02/15 06:00 [medline]
PHST- 2018/05/26 06:00 [entrez]
AID - S1471-4906(18)30086-3 [pii]
AID - 10.1016/j.it.2018.04.009 [doi]
PST - ppublish
SO  - Trends Immunol. 2018 Jul;39(7):577-590. doi: 10.1016/j.it.2018.04.009. Epub 2018 
      May 21.