PMID- 29794966
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20240329
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 6
DP  - 2018 May 24
TI  - Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the 
      Framingham Offspring Study.
LID - 10.3390/nu10060665 [doi]
LID - 665
AB  - Identification of diet and lifestyle risk factors for prevention of type 2 
      diabetes mellitus (T2DM) is of great importance. The specific role of dietary 
      cholesterol (DC) in T2DM risk is unclear. This study uses data from 2192 
      Framingham Offspring Study subjects to estimate the effects of DC alone and in 
      combination with markers of a healthy diet and other lifestyle factors on fasting 
      glucose and risk of T2DM or impaired fasting glucose (IFG) over 20 years of 
      follow-up. Dietary data were derived from two sets of three-day food records. 
      Statistical methods included mixed linear regression and Cox proportional 
      hazard's modeling to adjust for confounding. There were no statistically 
      significant differences in glucose levels over 20 years of follow-up across DC 
      intake categories (.
FAU - Baghdasarian, Siyouneh
AU  - Baghdasarian S
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. siyob@bu.edu.
FAU - Lin, Hsuan-Ping
AU  - Lin HP
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. hpl1201@bu.edu.
FAU - Pickering, Richard T
AU  - Pickering RT
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. rtpicker@bu.edu.
FAU - Mott, Melanie M
AU  - Mott MM
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. melaniemmott@yahoo.com.
FAU - Singer, Martha R
AU  - Singer MR
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. msinger@bu.edu.
FAU - Bradlee, M Loring
AU  - Bradlee ML
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. lbradlee@bu.edu.
FAU - Moore, Lynn L
AU  - Moore LL
AD  - Department of Medicine Section of Preventative Medicine and Epidemiology, Boston 
      University School of Medicine, Boston, MA 02118, USA. llmoore@bu.edu.
LA  - eng
GR  - N01HC25195/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20180524
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, Dietary)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cholesterol, Dietary/*administration & dosage/adverse effects
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*epidemiology
MH  - Diet, Healthy
MH  - Female
MH  - Health Surveys
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Massachusetts/epidemiology
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - *Recommended Dietary Allowances
MH  - Risk Factors
MH  - Time Factors
PMC - PMC6024792
OTO - NOTNLM
OT  - dietary cholesterol
OT  - eggs
OT  - fasting glucose
OT  - prospective study
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2018/05/26 06:00
MHDA- 2018/10/10 06:00
PMCR- 2018/06/01
CRDT- 2018/05/26 06:00
PHST- 2018/04/30 00:00 [received]
PHST- 2018/05/15 00:00 [revised]
PHST- 2018/05/18 00:00 [accepted]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - nu10060665 [pii]
AID - nutrients-10-00665 [pii]
AID - 10.3390/nu10060665 [doi]
PST - epublish
SO  - Nutrients. 2018 May 24;10(6):665. doi: 10.3390/nu10060665.