PMID- 29795012
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220330
IS  - 1999-4923 (Print)
IS  - 1999-4923 (Electronic)
IS  - 1999-4923 (Linking)
VI  - 10
IP  - 2
DP  - 2018 May 24
TI  - Magnetic Nanoparticles Conjugated with Peptides Derived from Monocyte 
      Chemoattractant Protein-1 as a Tool for Targeting Atherosclerosis.
LID - 10.3390/pharmaceutics10020062 [doi]
LID - 62
AB  - Atherosclerosis is a multifactorial inflammatory disease that may progress 
      silently for long period, and it is also widely accepted as the main cause of 
      cardiovascular diseases. To prevent atherosclerotic plaques from generating, 
      imaging early molecular markers and quantifying the extent of disease progression 
      are desired. During inflammation, circulating monocytes leave the bloodstream and 
      migrate into incipient lipid accumulation in the artery wall, following 
      conditioning by local growth factors and proinflammatory cytokines; therefore, 
      monocyte accumulation in the arterial wall can be observed in fatty streaks, 
      rupture-prone plaques, and experimental atherosclerosis. In this work, we 
      synthesized monocyte-targeting iron oxide magnetic nanoparticles (MNPs), which 
      were incorporated with the peptides derived from the chemokine receptor C-C 
      chemokine receptor type 2 (CCR2)-binding motif of monocytes chemoattractant 
      protein-1 (MCP-1) as a diagnostic tool for potential atherosclerosis. MCP-1-motif 
      MNPs co-localized with monocytes in in vitro fluorescence imaging. In addition, 
      with MNPs injection in ApoE knockout mice (ApoE KO mice), the well-characterized 
      animal model of atherosclerosis, MNPs were found in specific organs or regions 
      which had monocytes accumulation, especially the aorta of atherosclerosis model 
      mice, through in vivo imaging system (IVIS) imaging and magnetic resonance 
      imaging (MRI). We also performed Oil Red O staining and Prussian Blue staining to 
      confirm the co-localization of MCP-1-motif MNPs and atherosclerosis. The results 
      showed the promising potential of MCP-1-motif MNPs as a diagnostic agent of 
      atherosclerosis.
FAU - Kao, Chung-Wei
AU  - Kao CW
AD  - Department of Chemical Engineering, National Taiwan University, Taipei 10617, 
      Taiwan. r04524101@ntu.edu.tw.
FAU - Wu, Po-Ting
AU  - Wu PT
AD  - Department of Chemical Engineering, National Taiwan University, Taipei 10617, 
      Taiwan. r05524112@ntu.edu.tw.
FAU - Liao, Mei-Yi
AU  - Liao MY
AD  - Department of Applied Chemistry, National Pingtung University, Pingtung 90003, 
      Taiwan. myliao@mail.nptu.edu.tw.
FAU - Chung, I-Ju
AU  - Chung IJ
AD  - Department and Graduate Institute of Pharmacology College of Medicine, National 
      Taiwan University, Taipei 10617, Taiwan. r05458006@ntu.edu.tw.
FAU - Yang, Kai-Chien
AU  - Yang KC
AD  - Institute of Medical Device and Imaging, National Taiwan University, Taipei 
      10617, Taiwan. kcyang@ntu.edu.tw.
FAU - Tseng, Wen-Yih Isaac
AU  - Tseng WI
AD  - Department and Graduate Institute of Pharmacology College of Medicine, National 
      Taiwan University, Taipei 10617, Taiwan. wytseng@ntu.edu.tw.
AD  - Molecular Imaging Center, National Taiwan University, Taipei 10617, Taiwan. 
      wytseng@ntu.edu.tw.
FAU - Yu, Jiashing
AU  - Yu J
AUID- ORCID: 0000-0002-0782-2328
AD  - Department of Chemical Engineering, National Taiwan University, Taipei 10617, 
      Taiwan. jiayu@ntu.edu.tw.
AD  - Molecular Imaging Center, National Taiwan University, Taipei 10617, Taiwan. 
      jiayu@ntu.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20180524
PL  - Switzerland
TA  - Pharmaceutics
JT  - Pharmaceutics
JID - 101534003
PMC - PMC6027309
OTO - NOTNLM
OT  - MCP-1
OT  - atherosclerosis
OT  - iron oxide magnetic nanoparticle
OT  - monocytes
COIS- The authors declare no conflict of interest.
EDAT- 2018/05/26 06:00
MHDA- 2018/05/26 06:01
PMCR- 2018/06/01
CRDT- 2018/05/26 06:00
PHST- 2018/04/26 00:00 [received]
PHST- 2018/05/21 00:00 [revised]
PHST- 2018/05/21 00:00 [accepted]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/05/26 06:01 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - pharmaceutics10020062 [pii]
AID - pharmaceutics-10-00062 [pii]
AID - 10.3390/pharmaceutics10020062 [doi]
PST - epublish
SO  - Pharmaceutics. 2018 May 24;10(2):62. doi: 10.3390/pharmaceutics10020062.