PMID- 29795014
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20230926
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 15
IP  - 6
DP  - 2018 May 24
TI  - Prenatal Perfluorooctyl Sulfonate Exposure and Alu DNA Hypomethylation in Cord 
      Blood.
LID - 10.3390/ijerph15061066 [doi]
LID - 1066
AB  - BACKGROUND: Perfluoroalkyl substances (PFASs) are stable and persistent in the 
      environment, animals, and humans. PFASs can penetrate placenta and affect fetal 
      growth. We investigated associations between prenatal exposure to 
      perfluorooctanoic acid (PFOA), perfluorooctyl sulfonate (PFOS), perfluorononanoic 
      acid (PFNA), and perfluoroundecanoic acid (PFUA) and global methylation levels. 
      Specific Aims and Methods: The study used the subjects from Taiwan Birth Panel 
      birth cohort study, including all pregnant women who gave birth between July 2004 
      and June 2005 in four hospitals in Taipei city and New Taipei City. A total of 
      363 mother-infant pairs were included in the final analyses. PFOA, PFOS, PFNA, 
      and PFUA were measured by UPLC-MS/MS in cord blood. LINE-1 and Alu repeated 
      elements from cord blood was used to represent global DNA methylation levels. 
      Multivariable regression models were used to adjust potential confounders. 
      RESULTS: After controlling for potential confounders, each unit increase in the 
      natural log-transformed PFOS exposure was associated with an adjusted OR of 1.72 
      (95% CI: 1.03, 2.88) for low Alu methylation level when dichotomized methylation 
      level by medium. No significant effects between PFOA, PFNA, PFUA and methylation 
      levels in the multivariable regression models were observed. CONCLUSIONS: Our 
      findings suggest that prenatal PFOS exposure may be associated with low Alu 
      methylation level.
FAU - Liu, Chen-Yu
AU  - Liu CY
AD  - Institute of Environmental Health, College of Public Health, National Taiwan 
      University, Taipei 10055, Taiwan. chenyuliu@ntu.edu.tw.
FAU - Chen, Pau-Chung
AU  - Chen PC
AD  - Institute of Occupational Medicine and Industrial Hygiene, College of Public 
      Health, National Taiwan University, Taipei 10055, Taiwan. pchen@ntu.edu.tw.
FAU - Lien, Pei-Chen
AU  - Lien PC
AD  - Institute of Environmental Health, College of Public Health, National Taiwan 
      University, Taipei 10055, Taiwan. r01844006@ntu.edu.tw.
FAU - Liao, Yi-Peng
AU  - Liao YP
AD  - Institute of Environmental Health, College of Public Health, National Taiwan 
      University, Taipei 10055, Taiwan. katherinepope10@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180524
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Alkanesulfonic Acids)
RN  - 0 (Caprylates)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (perfluoroundecanoic acid)
RN  - 947VD76D3L (perfluorooctanoic acid)
RN  - 9H2MAI21CL (perfluorooctane sulfonic acid)
SB  - IM
MH  - Adult
MH  - Alkanesulfonic Acids
MH  - Alu Elements/*drug effects
MH  - Caprylates
MH  - Cohort Studies
MH  - DNA Methylation/*drug effects
MH  - Environmental Pollutants/blood
MH  - Fatty Acids
MH  - Female
MH  - Fetal Blood/*metabolism
MH  - Fluorocarbons/*adverse effects
MH  - Humans
MH  - Maternal Exposure/*adverse effects
MH  - Mothers
MH  - Pregnancy
MH  - Taiwan/epidemiology
MH  - Tandem Mass Spectrometry
PMC - PMC6025582
OTO - NOTNLM
OT  - DNA methylation
OT  - epigenetics
OT  - perfluoroalkyl substances
OT  - prenatal exposure
COIS- The authors declare no conflicts of interest.
EDAT- 2018/05/26 06:00
MHDA- 2019/01/29 06:00
PMCR- 2018/06/01
CRDT- 2018/05/26 06:00
PHST- 2018/04/30 00:00 [received]
PHST- 2018/05/18 00:00 [revised]
PHST- 2018/05/21 00:00 [accepted]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - ijerph15061066 [pii]
AID - ijerph-15-01066 [pii]
AID - 10.3390/ijerph15061066 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2018 May 24;15(6):1066. doi: 
      10.3390/ijerph15061066.