PMID- 29795464
OWN - NLM
STAT- MEDLINE
DCOM- 20200327
LR  - 20200327
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 43
IP  - 5
DP  - 2019 May
TI  - Gut hormone release after gastric bypass depends on the length of the 
      biliopancreatic limb.
PG  - 1009-1018
LID - 10.1038/s41366-018-0117-y [doi]
AB  - BACKGROUND/OBJECTIVES: Changes in gut hormone secretion are important for the 
      anti-diabetic effects of bariatric surgery. Roux-en-Y gastric bypass (RYGB) with 
      extended biliopancreatic limb (BPL) length may improve the metabolic outcomes 
      when compared to the classical procedure. The purpose of this study was to 
      compare the gut hormone responses to a liquid mixed meal after RYGB with one of 
      two different BPL lengths. SUBJECTS/METHODS: Non-diabetic weight-stable 
      individuals previously submitted to classical RYGB (n = 9; BPL length: 
      87.8 +/- 20.5 cm) or long BPL RYGB (n = 11; BPL length: 200 cm) underwent a liquid 
      mixed-meal tolerance test (MMTT). Blood was sampled at baseline and 15, 30, 45, 
      60, 90 and 120 min later for measurement of plasma glucose, enteropancreatic 
      hormones and total bile acids (TBA). RESULTS: Plasma glucose excursion curves 
      were similar in the two groups. The long BPL RYGB group displayed significantly 
      higher fasting and post-prandial GLP-1 (t = 0 min, p = 0.01 and t = 45 min, 
      p < 0.05; tAUC: 11,205 +/- 3399 vs 7889 +/- 1686 pmol/L x min, p = 0.02) and 
      neurotensin (t = 0 min, p = 0.02; t = 45 min, p < 0.05 and t = 60 min, p < 0.01; 
      tAUC: 18,392 +/- 7066 vs 11,437 +/- 3658 pmol/L x min, p = 0.02) levels, while 
      responses of GIP (t = 15 min, p < 0.01), insulin and C-peptide (t = 30 min, 
      p < 0.001) were lower as compared to classical RYGB. There were no differences in 
      glucagon, PP, PYY and TBA between the groups. CONCLUSIONS: RYGB with a longer BPL 
      results in a distinctive post-prandial hormone profile with augmented GLP-1 and 
      neurotensin responses that could be beneficial for the metabolic outcomes of the 
      surgery.
FAU - Patricio, Barbara G
AU  - Patricio BG
AD  - Clinical and Experimental Endocrinology, Department of Anatomy, Unit for 
      Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical 
      Sciences, University of Porto, Porto, Portugal.
FAU - Morais, Tiago
AU  - Morais T
AD  - Clinical and Experimental Endocrinology, Department of Anatomy, Unit for 
      Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical 
      Sciences, University of Porto, Porto, Portugal.
FAU - Guimaraes, Marta
AU  - Guimaraes M
AD  - Clinical and Experimental Endocrinology, Department of Anatomy, Unit for 
      Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical 
      Sciences, University of Porto, Porto, Portugal.
AD  - Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa 
      Maria da Feira, Portugal.
FAU - Veedfald, Simon
AU  - Veedfald S
AUID- ORCID: 0000-0002-0797-3417
AD  - NNF Center for Basic Metabolic Research & Department of Biomedical Sciences, 
      Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
FAU - Hartmann, Bolette
AU  - Hartmann B
AD  - NNF Center for Basic Metabolic Research & Department of Biomedical Sciences, 
      Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
FAU - Hilsted, Linda
AU  - Hilsted L
AD  - Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Holst, Jens J
AU  - Holst JJ
AD  - NNF Center for Basic Metabolic Research & Department of Biomedical Sciences, 
      Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
FAU - Nora, Mario
AU  - Nora M
AD  - Department of General Surgery, Centro Hospitalar de Entre o Douro e Vouga, Santa 
      Maria da Feira, Portugal.
FAU - Monteiro, Mariana P
AU  - Monteiro MP
AUID- ORCID: 0000-0002-0662-1831
AD  - Clinical and Experimental Endocrinology, Department of Anatomy, Unit for 
      Multidisciplinary Research in Biomedicine, Abel Salazar Institute of Biomedical 
      Sciences, University of Porto, Porto, Portugal. mpmonteiro@icbas.up.pt.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180524
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Gastrointestinal Hormones)
SB  - IM
MH  - Adult
MH  - Biliopancreatic Diversion
MH  - Diabetes Mellitus, Type 2/metabolism/*surgery
MH  - Female
MH  - *Gastric Bypass
MH  - Gastrointestinal Hormones/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/metabolism/physiopathology/*surgery
MH  - Prospective Studies
MH  - *Remission Induction
MH  - Treatment Outcome
MH  - Weight Loss/*physiology
EDAT- 2018/05/26 06:00
MHDA- 2020/03/28 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/02/21 00:00 [received]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/04/10 00:00 [revised]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2020/03/28 06:00 [medline]
PHST- 2018/05/26 06:00 [entrez]
AID - 10.1038/s41366-018-0117-y [pii]
AID - 10.1038/s41366-018-0117-y [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2019 May;43(5):1009-1018. doi: 10.1038/s41366-018-0117-y. Epub 
      2018 May 24.