PMID- 29795714
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1650-3414 (Print)
IS  - 1650-3414 (Electronic)
IS  - 1650-3414 (Linking)
VI  - 17
IP  - 1
DP  - 2006 Mar
TI  - The Role of Matrix Metalloproteinase-3 In the Development of Atherosclerosis and 
      Cardiovascular Events.
PG  - 2-5
AB  - The matrix metalloproteinases are a family of peptidase enzymes responsible for 
      the degradation of extracellular matrix (ECM). Alterations in the structure and 
      composition of the ECM play a key role in the atherogenic process. Recent data 
      suggest the important role of MMPs in the development of atherosclerosis and 
      future cardiovascular events. Expressed at low levels in normal tissue, MMPs are 
      upregulated in remodeling processes. Matrix metalloproteinase-3 (MMP-3) is 
      present in atherosclerotic plaques and acts in the degradation of the fibrous cap 
      of the atheroma. Many clinical studies reported that increased MMP-3 level and 
      also the gene polymorphism of MMP were the independent cardiovascular risk 
      factors. MMPs represent an attractive target to prevent matrix degradation, 
      atherosclerosis and possible cardiovascular events.
FAU - Magdalena, Krintus
AU  - Magdalena K
AD  - Department of Laboratory Medicine, Nicolaus Copernicus University in Torun, 
      Collegium Medicum in Bydgoszcz, Head: Prof. Grazyna Sypniewska, PhD.
FAU - Magdalena, Kuligowska
AU  - Magdalena K
AD  - Department of Laboratory Medicine, Nicolaus Copernicus University in Torun, 
      Collegium Medicum in Bydgoszcz, Head: Prof. Grazyna Sypniewska, PhD.
FAU - Grazyna, Sypniewska
AU  - Grazyna S
AD  - Department of Laboratory Medicine, Nicolaus Copernicus University in Torun, 
      Collegium Medicum in Bydgoszcz, Head: Prof. Grazyna Sypniewska, PhD.
LA  - eng
PT  - Journal Article
DEP - 20060320
PL  - Italy
TA  - EJIFCC
JT  - EJIFCC
JID - 101092742
PMC - PMC5954426
OTO - NOTNLM
OT  - atherosclerosis
OT  - extracellular matrix
OT  - matrix metalloproteinase-3
OT  - matrix metalloproteinases
OT  - polymorphism
OT  - remodeling
EDAT- 2006/03/20 00:00
MHDA- 2006/03/20 00:01
PMCR- 2006/03/20
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2006/03/20 00:00 [pubmed]
PHST- 2006/03/20 00:01 [medline]
PHST- 2006/03/20 00:00 [pmc-release]
AID - ejifcc-17-002 [pii]
PST - epublish
SO  - EJIFCC. 2006 Mar 20;17(1):2-5. eCollection 2006 Mar.