PMID- 2979611
OWN - NLM
STAT- MEDLINE
DCOM- 19920127
LR  - 20190919
IS  - 0891-6934 (Print)
IS  - 0891-6934 (Linking)
VI  - 1
IP  - 2
DP  - 1988
TI  - Immunological studies of HTLV-I associated myelopathy.
PG  - 125-31
AB  - We report the immunological studies of 50 cases with a chronic progressive 
      myelopathy associated with elevated antibodies to human T-cell lymphotropic virus 
      type I (HTLV-I) and adult T-cell leukemia-like cells (HAM). These are as follows: 
      (1) T-cell activation; (2) increase of the OKT4/OKT8 ratio, due mostly to 
      increased inducer/helper T cells and/or decreased suppressor/cytotoxic T cells; 
      (3) decrease of natural killer cell numbers and activity; and (4) increase of 
      immunoglobulins (IgG, IgA). Our results provide evidence that autoimmune events 
      may participate in the pathogenesis of HAM and may be relevant in the hypothesis 
      of common immune mechanisms between HAM and HTLV-I positive tropical spastic 
      paraparesis.
FAU - Kitajima, I
AU  - Kitajima I
AD  - Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 
      Japan.
FAU - Osame, M
AU  - Osame M
FAU - Izumo, S
AU  - Izumo S
FAU - Igata, A
AU  - Igata A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (Immunoglobulins)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Complement System Proteins/analysis
MH  - Female
MH  - HTLV-I Antibodies/*analysis
MH  - Humans
MH  - Immunoglobulins/analysis
MH  - Killer Cells, Natural/immunology
MH  - Leukemia, T-Cell/immunology
MH  - Lymphocyte Activation
MH  - Lymphocyte Subsets/immunology
MH  - Male
MH  - Middle Aged
MH  - Spinal Cord Diseases/*immunology
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.3109/08916938809001925 [doi]
PST - ppublish
SO  - Autoimmunity. 1988;1(2):125-31. doi: 10.3109/08916938809001925.