PMID- 29797702
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230202
IS  - 1613-4133 (Electronic)
IS  - 1613-4125 (Linking)
VI  - 62
IP  - 14
DP  - 2018 Jul
TI  - Obesity-Associated Diseases Biomarkers Are Differently Modulated in Lean and 
      Obese Individuals and Inversely Correlated to Plasma Polyphenolic Metabolites 
      After 6 Weeks of Mango (Mangifera indica L.) Consumption.
PG  - e1800129
LID - 10.1002/mnfr.201800129 [doi]
AB  - SCOPE: Mangos are a rich source of gallotannin-derived polyphenols that may exert 
      anti-inflammatory effects relevant to obesity-related chronic diseases. This 
      randomized human clinical study investigated the influence of daily mango 
      supplementation for 6 weeks on inflammation and metabolic functions in lean and 
      obese individuals. METHODS AND RESULTS: Lean (n = 12, body mass index [BMI] 
      18-26.2 kg m(-2) ) and obese (n = 9, BMI >28.9 kg m(-2) ) participants, aged 
      18-65 years received daily 400 g of mango pulp for 6 weeks. Inflammatory 
      cytokines, metabolic hormones, and lipid profiles were examined in plasma before 
      and after 6 weeks. In lean participants, systolic blood pressure was lowered by 4 
      mmHg after 6 weeks. In obese participants, hemoglobin A1c (HbA1c) and plasminogen 
      activator inhibitor-1 (PAI-1) were reduced by 18% and 20%, respectively. Obese 
      participants showed decreased plasma concentrations (area under the curve [AUC] 
      (0-8h) ) of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1). 
      Correlation analysis indicates that the beneficial effects of mango 
      supplementation on pro-inflammatory cytokines, PAI-1 and HbA1c, are associated 
      with systemic exposure to polyphenolic metabolites. CONCLUSIONS: Mango 
      supplementation improves the plasma levels of pro-inflammatory cytokines and 
      metabolic hormones in obese participants. There is a crucial need to investigate 
      the role of lowered polyphenolic absorption in obese individuals on their 
      efficacy in reducing biomarkers for inflammation and other risk factors for 
      chronic diseases.
CI  - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Fang, Chuo
AU  - Fang C
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Kim, Hyemee
AU  - Kim H
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Barnes, Ryan C
AU  - Barnes RC
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Talcott, Stephen T
AU  - Talcott ST
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
FAU - Mertens-Talcott, Susanne U
AU  - Mertens-Talcott SU
AD  - Department of Nutrition and Food Science, Texas A&M University, College Station, 
      77843, TX, USA.
LA  - eng
GR  - National Mango Board/
PT  - Journal Article
DEP - 20180621
PL  - Germany
TA  - Mol Nutr Food Res
JT  - Molecular nutrition & food research
JID - 101231818
SB  - IM
OTO - NOTNLM
OT  - clinical study
OT  - gallotannin derivatives
OT  - inflammation
OT  - metabolic functions
OT  - obesity
EDAT- 2018/05/26 06:00
MHDA- 2018/05/26 06:01
CRDT- 2018/05/26 06:00
PHST- 2018/05/03 00:00 [revised]
PHST- 2018/02/02 00:00 [received]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/05/26 06:01 [medline]
PHST- 2018/05/26 06:00 [entrez]
AID - 10.1002/mnfr.201800129 [doi]
PST - ppublish
SO  - Mol Nutr Food Res. 2018 Jul;62(14):e1800129. doi: 10.1002/mnfr.201800129. Epub 
      2018 Jun 21.