PMID- 29797950
OWN - NLM
STAT- MEDLINE
DCOM- 20181025
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 31
IP  - 20
DP  - 2017 Oct 20
TI  - [Preliminary findings for metabolite profiles of papillary thyroid carcinoma and 
      laryngeal squamous cell carcinoma].
PG  - 1561-1565
LID - 10.13201/j.issn.1001-1781.2017.20.005 [doi]
AB  - Objective:To identify distinct metabolite profiles of papillary thyroid cancer 
      (PTC) and laryngeal squamous cell carcinoma (LSCC).Method:Tumor and adjacent 
      non-tumor specimens were collected from 57 PTC and 33 LSCC patients. Distinct 
      metabolite profiles of tissues were examined using a combination of gas 
      chromatography-time-of-flight mass spectrometry and ultra-performance liquid 
      chromatography-quadrupole-time-of-flight mass spectrometry. The data were 
      analyzed with multivariate statistical analysis to compare the distinct 
      metabolite profiles and related pathways of these three tumors.Result:A panel of 
      46 and 41 differentially expressed metabolites were identified in tumor and 
      adjacent non-tumor tissues of PTC and LSCC, respectively. Increased glycolysis, 
      amino acids metabolism, one carbon metabolism and tryptophan metabolism were 
      found in these two types of tumor tissues compared to adjacent non tumor tissues. 
      Purine and pyrimidine metabolism was significantly elevated in PTC and LSCC tumor 
      tissues, while taurine and hypotaurine were only higher in PTC tumor tissues. The 
      fatty acid metabolism was detected at lower level in both PTC and LSCC tumor 
      tissue.Conclusion:PTC and LSCC tumor tissues not only have common metabolic 
      signatures characterized by increased glycolysis, amino acids metabolism, one 
      carbon metabolism and tryptophan metabolism, but also have distinct metabolic 
      signatures. It is helpful to understand the nature of these two tumors.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Fei, M J
AU  - Fei MJ
AD  - Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200001, China.
FAU - Xu, Y N
AU  - Xu YN
AD  - Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200001, China.
FAU - Wang, J D
AU  - Wang JD
AD  - Department of Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai 
      Jiao Tong University, Shanghai, 200001, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Amino Acids)
RN  - 7440-44-0 (Carbon)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Amino Acids/metabolism
MH  - Carbon/metabolism
MH  - Carcinoma, Papillary/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism
MH  - Metabolome
MH  - Thyroid Cancer, Papillary
MH  - Thyroid Neoplasms/*metabolism
MH  - Tryptophan/metabolism
OTO - NOTNLM
OT  - gas chromatography-time-of-flight mass spectrometry
OT  - laryngeal squamous cell carcinoma
OT  - metabolomics
OT  - thyroid neoplasms
OT  - ultra-performance liquid chromatography-quadrupole-time-of-flight mass 
      spectrometry
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2018/05/26 06:00
MHDA- 2018/10/26 06:00
CRDT- 2018/05/26 06:00
PHST- 2017/08/03 00:00 [received]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/10/26 06:00 [medline]
AID - 10.13201/j.issn.1001-1781.2017.20.005 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Oct 20;31(20):1561-1565. 
      doi: 10.13201/j.issn.1001-1781.2017.20.005.