PMID- 29798074
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 32
IP  - 7
DP  - 2018 Apr
TI  - [Correlation study between the levels of serum MCP-1,SAA and cognitive function 
      in patients with COPD-OSAHS].
PG  - 485-488
LID - 10.13201/j.issn.1001-1781.2018.07.002 [doi]
AB  - Objective:To study the correlation among the serum monocyte chemoattractant 
      protein-1 (MCP-1),serum amyloid A(SAA) and the level of cognitive function in 
      patients with chronic obstructive pulmonary disease and obstructive sleep apnea 
      hypopnea syndrome overlap syndrome(OS).Method:Sixty patients with OS were in the 
      experimental group, and 33 patients with COPD were in control group. The serum 
      levels of MCP-1 and SAA were measured, and the correlation among MCP-1, SAA and 
      cognitive function was observed by the Montreal scale.Result:1 in circleThe serum levels of 
      MCP-1 and SAA in OS group were (159.85+/-21.38)ng/L and (122.64+/-42.49)ng/L 
      respectively,which in control group were (135.02+/-15.31)ng/L and (71.37+/-10.16)ng/L 
      respectively.There were the was statistically significant difference between the 
      two groups(P<0.05). 2 in circleMontreal scale score and its sub items in OS group were 
      lower than the control group.The difference was statistically significant 
      (P<0.05).3 in circleThere was significant negative correlation between Montreal scale and 
      the serum levels of MCP-1(r=-0.654,P<0.05) and SAA (r=-0.617,P<0.05) in OS 
      group.Conclusion:Patients in the OS group had obvious cognitive impairment 
      compared with the ones in control group, which suggested that OSAHS might be an 
      independent risk factor for cognitive impairment. The cognitive function of OS 
      patients was negatively related to MCP-1 and SAA, which suggested that MCP-1 and 
      SAA played a role in the occurrence of cognitive impairment in OS patients.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Ge, Y L
AU  - Ge YL
AD  - Department of Respiratory, North China University of Science and Technology 
      Affiliated Hospital,Tangshan,063000, China.
FAU - Liu, C H
AU  - Liu CH
FAU - Fu, A S
AU  - Fu AS
FAU - Wang, H Y
AU  - Wang HY
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Serum Amyloid A Protein)
SB  - IM
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Cognition
MH  - Cognitive Dysfunction/blood/*complications
MH  - Humans
MH  - Polysomnography
MH  - Pulmonary Disease, Chronic Obstructive/blood/*complications
MH  - Risk Factors
MH  - Serum Amyloid A Protein/*analysis
MH  - Sleep Apnea, Obstructive/blood/*complications
OTO - NOTNLM
OT  - chronic obstructive pulmonary disease
OT  - cognitive function
OT  - montreal cognitive assessment
OT  - serum amyloid a protein
OT  - serum monocyte chemotactic protein-1
OT  - sleep apnea hypopnea syndrome,obstructive
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2018/05/26 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/05/26 06:00
PHST- 2017/11/30 00:00 [received]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
AID - 10.13201/j.issn.1001-1781.2018.07.002 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Apr;32(7):485-488. doi: 
      10.13201/j.issn.1001-1781.2018.07.002.