PMID- 29798204
OWN - NLM
STAT- MEDLINE
DCOM- 20181019
LR  - 20220330
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 32
IP  - 1
DP  - 2018 Jan 5
TI  - [Expression of long non-coding RNA LINC00460 in laryngeal squamous cell carcinoma 
      tissue and its clinical significance].
PG  - 18-22
LID - 10.13201/j.issn.1001-1781.2018.01.004 [doi]
AB  - Objective:To understand the expression of LINC00460 in laryngeal squamous cell 
      carcinoma (LSCC), and to discuss the role of LINC00460 in carcinogenesis and 
      development of laryngeal squamous cell carcinoma. Method:The expression of 
      LINC00460 in 68 laryngeal squamous cell carcinoma tissues and paired adjacent 
      normal tissues were examined by real-time PCR. The relationship between the 
      expression levels of LINC00460 and the clinicopathological features including 
      clinical stage, histological grade, pathological type, and lymph node metastasis 
      in LSCC was analyzed according to the clinical data. Result:The expression of 
      LINC00460 was significantly upregulated in the LSCC tissue compared with that of 
      adjacent normal mucosal tissue (P=0.006). There were no statistical differences 
      of the quantity of LINC00460 expression among supraglottic, glottic and 
      subglottic LSCC (P>0.05). Moreover, LINC00460 had no significant changes in 
      poorly differentiated LSCC when compared with that of well and moderately 
      differentiated LSCC (P>0.05). Furthermore, the expression of LINC00460 in LSCC 
      with lymph node metastasis had no significant changes when compared with that 
      without of lymph node metastasis (P>0.05). Notably, LINC00460 expression in T1+T2 
      stages patients were significantly lower than T3+T4 stages (P<0.05). 
      Conclusiont:Upregulation of long non-coding RNA LINC00460 might contribute to the 
      carcinogenesis and development of LSCC, furthermore play important biological 
      function.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Ge, S S
AU  - Ge SS
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
FAU - Wu, Y Y
AU  - Wu YY
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
FAU - Gao, W
AU  - Gao W
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
FAU - Zhang, C M
AU  - Zhang CM
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
FAU - Hou, J
AU  - Hou J
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
FAU - Wen, S X
AU  - Wen SX
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
FAU - Wang, B Q
AU  - Wang BQ
AD  - Department of Otolaryngology,the First Hospital of Shanxi Medical 
      University,Taiyuan, 030001, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Biomarkers, Tumor
MH  - Carcinoma, Squamous Cell/*diagnosis
MH  - Humans
MH  - Laryngeal Neoplasms/*diagnosis
MH  - Prognosis
MH  - RNA, Long Noncoding/*analysis
OTO - NOTNLM
OT  - biomarker
OT  - invasion
OT  - laryngeal squamous cell carcinoma
OT  - long non-coding RNA
OT  - metastasis
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2018/05/26 06:00
MHDA- 2018/10/20 06:00
CRDT- 2018/05/26 06:00
PHST- 2017/11/02 00:00 [received]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/10/20 06:00 [medline]
AID - 10.13201/j.issn.1001-1781.2018.01.004 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018 Jan 5;32(1):18-22. doi: 
      10.13201/j.issn.1001-1781.2018.01.004.