PMID- 29798252
OWN - NLM
STAT- MEDLINE
DCOM- 20181112
LR  - 20181112
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 31
IP  - 14
DP  - 2017 Jul 20
TI  - [The relationship between (1)(8)F-FDG uptake and oncogene in human laryngeal squamous 
      cell carcinoma transplantation tumor animal model].
PG  - 1108-1112
LID - 10.13201/j.issn.1001-1781.2017.14.014 [doi]
AB  - Objective:The aim of this study is to explore the relationship between [F18] 
      fluoro 2 deoxy d glucose (1)(8)F-FDG) uptake and oncogene expression in human 
      laryngeal squamous cell carcinoma (LSCC) transplantation tumor.Method:Ten nude 
      mice were randomly divided into two groups, 5 mice of each group. One group was 
      injected subcutaneously with Hep-2 cells to establish xenograft model, and the 
      other one was injected with HIF-RNAi-Hep-2 cells. All animals were conducted with 
      positron emission tomography computed tomography PET scan. The average tumor T/N 
      ratio was calculated. After PET scanning, tumor tissue was picked off for 
      immunohistochemical examination.Result:The tumor imaging were both clear and 
      there was no significant difference between these two groups (P> 0.05). The 
      expression of hypoxia inducible factor 1 alpha (HIF-1alpha), glucose transporter 
      protein-1 (GLUT-1) and vascular endothelial growth factor (VEGF) were high in 
      Hep-2 group. The expression of HIF-1alpha was lower in HIF-RNAi-Hep-2 group (P< 
      0.05). But there was no significant difference about the expression of GLUT-1 and 
      VEGF between these two groups (P> 0.05).Conclusion:The oncogenic pathway 
      activated in LSCC is related with the uptake of (1)(8)F-FDG. The glycolysis gene and 
      vascular factor maybe play a critical role.
CI  - Copyright(c) by the Editorial Department of Journal of Clinical Otorhinolaryngology 
      Head and Neck Surgery.
FAU - Xu, O
AU  - Xu O
AD  - Department of Otorhinolaryngology, the Second Hospital of Hebei Medical 
      University, Shijiazhuang, 050000, China.
FAU - Wang, Y B
AU  - Wang YB
AD  - Department of Otorhinolaryngology, the Second Hospital of Hebei Medical 
      University, Shijiazhuang, 050000, China.
FAU - Shan, C G
AU  - Shan CG
AD  - Department of Otorhinolaryngology, the Second Hospital of Hebei Medical 
      University, Shijiazhuang, 050000, China.
FAU - Zhang, L
AU  - Zhang L
AD  - Department of PET Center, Bethune International Peace Hospital.
FAU - Li, X M
AU  - Li XM
AD  - Department of Otorhinolaryngology Head Neck Surgery, Bethune International Peace 
      Hospital.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - 0 (Glucose Transporter Type 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Animals
MH  - Carcinoma, Squamous Cell/diagnostic imaging/*metabolism
MH  - Fluorodeoxyglucose F18/*pharmacokinetics
MH  - Glucose Transporter Type 1
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Laryngeal Neoplasms/diagnostic imaging/*metabolism
MH  - Mice
MH  - Mice, Nude
MH  - Positron-Emission Tomography
MH  - Random Allocation
MH  - Transplantation, Heterologous
MH  - Vascular Endothelial Growth Factor A/metabolism
OTO - NOTNLM
OT  - glycolysis
OT  - hypoxia
OT  - laryngeal squamous cell carcinoma
OT  - transplantation tumor
OT  - (1)(8)F-FDG PET
COIS- The authors of this article and the planning committee members and staff have no 
      relevant financial relationships with commercial interests to disclose.
EDAT- 2018/05/26 06:00
MHDA- 2018/11/13 06:00
CRDT- 2018/05/26 06:00
PHST- 2017/02/03 00:00 [received]
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/11/13 06:00 [medline]
AID - 10.13201/j.issn.1001-1781.2017.14.014 [doi]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jul 20;31(14):1108-1112. 
      doi: 10.13201/j.issn.1001-1781.2017.14.014.