PMID- 29798692
OWN - NLM
STAT- MEDLINE
DCOM- 20200618
LR  - 20200618
IS  - 1029-2330 (Electronic)
IS  - 1026-7158 (Linking)
VI  - 27
IP  - 3
DP  - 2019 Mar
TI  - Recent advances in electrospun for drug delivery purpose.
PG  - 270-282
LID - 10.1080/1061186X.2018.1481413 [doi]
AB  - Electrospun, an advanced technology, has been successfully employed for fibre 
      production and offers many merits in novel drug delivery systems (DDSs). In 
      recent years, electrospun has gained significant attention and attraction of the 
      scientists in soaring numbers. This technology is superior to other technologies 
      in fabricating the fibres which range from micrometers to manometers scale. The 
      selection of appropriate polymers, electrospun processes and electrospun 
      parameters play important roles in controlling the drug release while, treating 
      serious illness. Besides, electrospraying process has similar characteristics to 
      the electrospun and is presented briefly here. Further, in vivo and in vitro 
      evaluations of the electrospun nanofibers are comprehensively discussed. In 
      addition, the electrospun nanotechnology has been exploited to design drug 
      release systems, investigate drug's pharmacokinetics and further develop DDS. The 
      electrospun nanofibers improve bioactivity of various types of drugs including 
      water-insoluble, soluble, anticancer and antibacterial drugs and genetic 
      materials. In the end, the prospects and challenges in the process of designing 
      drug-loaded electrospun nanofibers are discussed in detail.
FAU - Liu, Mengyao
AU  - Liu M
AD  - a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan 
      , China.
FAU - Zhang, Yanan
AU  - Zhang Y
AD  - a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan 
      , China.
FAU - Sun, Siyu
AU  - Sun S
AD  - a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan 
      , China.
FAU - Khan, Abdur Rauf
AU  - Khan AR
AD  - a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan 
      , China.
FAU - Ji, Jianbo
AU  - Ji J
AD  - a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan 
      , China.
FAU - Yang, Mingshi
AU  - Yang M
AD  - b Department of Pharmacy, Faculty of Health and Medical Sciences , University of 
      Copenhagen , Copenhagen , Denmark.
FAU - Zhai, Guangxi
AU  - Zhai G
AD  - a Department of Pharmaceutics, College of Pharmacy , Shandong University , Jinan 
      , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180808
PL  - England
TA  - J Drug Target
JT  - Journal of drug targeting
JID - 9312476
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - *Drug Delivery Systems
MH  - *Drug Design
MH  - Drug Liberation
MH  - Humans
MH  - *Nanofibers
MH  - Particle Size
MH  - Pharmaceutical Preparations/administration & dosage/chemistry
MH  - Solubility
MH  - Technology, Pharmaceutical/methods
OTO - NOTNLM
OT  - Electrospun
OT  - drug delivery system
OT  - electrospraying
OT  - electrospun nanofibers
OT  - polymers
EDAT- 2018/05/26 06:00
MHDA- 2020/06/19 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2020/06/19 06:00 [medline]
PHST- 2018/05/26 06:00 [entrez]
AID - 10.1080/1061186X.2018.1481413 [doi]
PST - ppublish
SO  - J Drug Target. 2019 Mar;27(3):270-282. doi: 10.1080/1061186X.2018.1481413. Epub 
      2018 Aug 8.