PMID- 29798961
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20221207
IS  - 1998-4774 (Electronic)
IS  - 0019-509X (Linking)
VI  - 54
IP  - 3
DP  - 2017 Jul-Sep
TI  - Prevalence of cytogenetic abnormalities in chronic lymphocytic leukemia in the 
      southern part of Turkey.
PG  - 572-575
LID - 10.4103/ijc.IJC_291_17 [doi]
AB  - BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common type of 
      leukemia among adults in Western populations. CLL has a wide range of clinical 
      presentations and varied outcomes. For CLL, cytogenetic assessment is essential 
      for estimating prognoses and determining the treatment of choice. The 
      fluorescence in situ hybridization (FISH) technique is widely used for genetic 
      assessment due to its high sensitivity. AIM: This study aimed to evaluate the 
      frequencies of deletions of 13q14.3, 17p13.1, 11q22.3, and 13q34 and of trisomy 
      12 and to observe their effects on survival in 226 Turkish CLL patients using 
      FISH analysis. RESULT AND CONCLUSION: The frequencies of abnormalities were 65.4% 
      for del 13q14.3, 39.8% for del 17p13.1, 19% for del 11q22.3 (del ATM), and 15.9% 
      for trisomy 12. No patients had a 13q34.3 aberration. Our results are partially 
      consistent with literature findings. However, certain conflicts with prior 
      results were observed, particularly with respect to the high prevalence of 
      17p13.1 deletions and the enhanced survival of patients with such deletions. 
      These inconsistencies may represent population-based differences in the genetic 
      epidemiology of CLL.
FAU - Bagir, Emine Kilic
AU  - Bagir EK
AD  - Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey.
FAU - Acikalin, Arbil
AU  - Acikalin A
AD  - Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey.
FAU - Alsancak, Perihan
AU  - Alsancak P
AD  - Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey.
FAU - Paydas, Semra
AU  - Paydas S
AD  - Department of Medical Oncology, Faculty of Medicine, Cukurova University, Adana, 
      Turkey.
FAU - Gurkan, Emel
AU  - Gurkan E
AD  - Department of Hematology, Faculty of Medicine, Cukurova University, Adana, 
      Turkey.
FAU - Ergin, Melek
AU  - Ergin M
AD  - Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Cancer
JT  - Indian journal of cancer
JID - 0112040
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - *Chromosome Aberrations
MH  - Female
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Trisomy/*pathology
MH  - Turkey/epidemiology
OTO - NOTNLM
OT  - B-cell
OT  - chronic lymphocytic
OT  - cytogenetic
OT  - fluorescence in situ hybridization
OT  - leukemia
COIS- There are no conflicts of interest
EDAT- 2018/05/26 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/05/26 06:00
PHST- 2018/05/26 06:00 [entrez]
PHST- 2018/05/26 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
AID - IndianJournalofCancer_2017_54_3_572_233141 [pii]
AID - 10.4103/ijc.IJC_291_17 [doi]
PST - ppublish
SO  - Indian J Cancer. 2017 Jul-Sep;54(3):572-575. doi: 10.4103/ijc.IJC_291_17.