PMID- 29799175 OWN - NLM STAT- MEDLINE DCOM- 20190419 LR - 20190419 IS - 1860-7314 (Electronic) IS - 1860-6768 (Linking) VI - 14 IP - 1 DP - 2019 Jan TI - Are We There Yet? How and When Specific Biotechnologies Will Improve Human Health. PG - e1800195 LID - 10.1002/biot.201800195 [doi] AB - Patient X: A 67-year-old Caucasian man slips on a patch of ice. He has abrasions to his hands and has sustained significant damage to his hip. At the emergency room, he informs clinicians he takes atorvastatin, metformin, and glimepiride to treat hypertension and Type 2 Diabetes Mellitus (T2DM). X-rays reveal a fractured hip, which will require total hip replacement surgery. CI - (c) 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. FAU - O'Day, Elizabeth AU - O'Day E AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Olaris Therapeutics, Inc., 45 Moulton St., Cambridge, MA, 02138, USA. FAU - Hosta-Rigau, Leticia AU - Hosta-Rigau L AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, Technical University of Denmark, 2800, Kongens Lyngby, Denmark. FAU - Oyarzun, Diego A AU - Oyarzun DA AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Department of Mathematics, Imperial College London, London, SW7 2AZ, UK. AD - EPSRC Centre for Mathematics of Precision Healthcare, Imperial College London, London, SW7 2AZ, UK. FAU - Okano, Hideyuki AU - Okano H AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. FAU - de Lorenzo, Victor AU - de Lorenzo V AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - National Center of Biotechnology CSIC, Systems Biology Program, Campus de Cantoblanco, E-28049, Madrid, Spain. FAU - von Kameke, Conrad AU - von Kameke C AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - BioInnovators Europe, Berlin, Germany. FAU - Alsafar, Habiba AU - Alsafar H AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Khalifa University Center for Biotechnology, Khalifa University, PO Box 127788, Abu Dhabi, United Arab Emirates. FAU - Cao, Cong AU - Cao C AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - University of Nottingham, 199 East Taikang Road, Ningbo, 315100, China. FAU - Chen, Guo-Qiang AU - Chen GQ AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Center for Synthetic and Systems Biology, MOE Lab for Industrial Biocatalysis, Tsinghua-Peking University Center of Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China. FAU - Ji, Weizhi AU - Ji W AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Kunming University of Science and Technology, 727 Jingming South Rd. Chenh Gong, Kunming, 650500, Yunnan, China. FAU - Roberts, Richard J AU - Roberts RJ AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - New England Biolabs, 240 County Road, Ipswich, MA, 01938, USA. FAU - Ronaghi, Mostafa AU - Ronaghi M AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Illumina Inc., 5200 Illumina Way, San Diego, CA, 92121, USA. FAU - Yeung, Karen AU - Yeung K AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Law School and School of Computer Science University of Birmingham, Birmingham, UK, B15 2TT. FAU - Zhang, Feng AU - Zhang F AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. AD - McGovern Institute for Brain Research at MIT, Cambridge, MA, 02139, USA. AD - Department of Brain and Cognitive Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. FAU - Lee, Sang Yup AU - Lee SY AUID- ORCID: 0000-0003-0599-3091 AD - Global Future Council on the Future of Biotechnologies, World Economic Forum, Cologny, CH-1223, Geneva, Switzerland. AD - Department of Chemical and Biomolecular Engineering (BK21 Plus program), Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-Ro, Daejeon, 34141, Republic of Korea. AD - The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet Bygning 220, 2800, Kongens Lyngby, Denmark. LA - eng PT - Journal Article PT - Review DEP - 20180613 PL - Germany TA - Biotechnol J JT - Biotechnology journal JID - 101265833 SB - IM MH - Biotechnology/*methods MH - Gene Editing MH - Humans MH - Precision Medicine MH - *Public Health MH - Tissue Engineering OTO - NOTNLM OT - biotechnology OT - gene editing OT - precision medicine OT - stem cells OT - tissue engineering EDAT- 2018/05/26 06:00 MHDA- 2019/04/20 06:00 CRDT- 2018/05/26 06:00 PHST- 2018/04/15 00:00 [received] PHST- 2018/05/11 00:00 [revised] PHST- 2018/05/26 06:00 [pubmed] PHST- 2019/04/20 06:00 [medline] PHST- 2018/05/26 06:00 [entrez] AID - 10.1002/biot.201800195 [doi] PST - ppublish SO - Biotechnol J. 2019 Jan;14(1):e1800195. doi: 10.1002/biot.201800195. Epub 2018 Jun 13.