PMID- 29802953
OWN - NLM
STAT- MEDLINE
DCOM- 20180911
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 142
DP  - 2018 Aug
TI  - Impact of prolonged neuromuscular electrical stimulation on metabolic profile and 
      cognition-related blood parameters in type 2 diabetes: A randomized controlled 
      cross-over trial.
PG  - 37-45
LID - S0168-8227(18)30072-X [pii]
LID - 10.1016/j.diabres.2018.05.032 [doi]
AB  - AIMS: This study aimed to examine the effect of prolonged neuromuscular 
      electrical stimulation (NMES) on the metabolic profile and cognition-related 
      blood parameters in patients with type 2 diabetes mellitus (T2DM). METHODS: 
      Fourteen patients with T2DM (63.2 +/- 3.0 years, 76.1 +/- 3.5 kg) participated in a 
      randomized controlled cross-over study, in which 8-week-long NMES interventions 
      were performed on both legs. The NMES training protocol consisted of 40-min 
      sessions, 5 days per week, for 8 weeks. The relative changes in glucose and lipid 
      profiles, and cognition-related blood parameters were evaluated. RESULTS: NMES 
      training induced significant changes in the fasting glucose concentration 
      (p < 0.05) and percent body fat (p < 0.05), although there were no significant 
      changes in HbA1c and blood lipid levels (p >/= 0.05). The change in plasma 
      brain-derived neurotrophic factor (BDNF) levels was significantly higher in the 
      NMES period than in the control period (p < 0.05). CONCLUSIONS: This study showed 
      that an 8-week NMES training program could induce greater changes in the blood 
      glucose concentration, percent body fat, and plasma BDNF levels than the control 
      intervention in patients with T2DM. NMES training might prove to be an 
      alternative exercise method for patients who might have difficulties in 
      performing adequate voluntary exercise.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Miyamoto, Toshiaki
AU  - Miyamoto T
AD  - School of Rehabilitation, Hyogo University of Health Sciences, Kobe, Japan. 
      Electronic address: t-miyamoto@huhs.ac.jp.
FAU - Iwakura, Toshio
AU  - Iwakura T
AD  - Department of Diabetes and Endocrinology, Kobe City Medical Center General 
      Hospital, Kobe, Japan.
FAU - Matsuoka, Naoki
AU  - Matsuoka N
AD  - Department of Diabetes and Endocrinology, Kobe City Medical Center General 
      Hospital, Kobe, Japan.
FAU - Iwamoto, Masako
AU  - Iwamoto M
AD  - Nutrition Management Department, Kobe City Medical Center General Hospital, Kobe, 
      Japan.
FAU - Takenaka, Mariko
AU  - Takenaka M
AD  - Nutrition Management Department, Kobe City Medical Center General Hospital, Kobe, 
      Japan.
FAU - Akamatsu, Yasunori
AU  - Akamatsu Y
AD  - Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 
      Japan.
FAU - Moritani, Toshio
AU  - Moritani T
AD  - Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180524
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognition/*physiology
MH  - Cross-Over Studies
MH  - Diabetes Mellitus, Type 2/*therapy
MH  - Electric Stimulation Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolome/*physiology
MH  - Middle Aged
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Electrical muscle stimulation
OT  - Exercise
OT  - Metabolism
EDAT- 2018/05/29 06:00
MHDA- 2018/09/12 06:00
CRDT- 2018/05/27 06:00
PHST- 2018/01/12 00:00 [received]
PHST- 2018/05/02 00:00 [revised]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/05/29 06:00 [pubmed]
PHST- 2018/09/12 06:00 [medline]
PHST- 2018/05/27 06:00 [entrez]
AID - S0168-8227(18)30072-X [pii]
AID - 10.1016/j.diabres.2018.05.032 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Aug;142:37-45. doi: 10.1016/j.diabres.2018.05.032. 
      Epub 2018 May 24.