PMID- 29803000
OWN - NLM
STAT- MEDLINE
DCOM- 20180622
LR  - 20180622
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 670
DP  - 2018 Sep 5
TI  - HLA-B*27 subtypes and their implications in the pathogenesis of ankylosing 
      spondylitis.
PG  - 15-21
LID - S0378-1119(18)30589-4 [pii]
LID - 10.1016/j.gene.2018.05.092 [doi]
AB  - Ankylosing spondylitis (AS) is a highly heritable kind of arthritis that affects 
      the vertebral column. AS risk has been associated strongly with Human leukocyte 
      antigen (HLA)-B*27. In fact, some HLA-B*27 subtypes have been associated with the 
      increased disease risk, although some specific subtypes have not shown such 
      associations. It is supposed that HLA-B*27 plays a major role in the 
      etiopathogenesis of the disease. However, the difference in pathogenic outcomes 
      of HLA-B*27 certain subtypes needs to be clarified. The purpose of this review 
      article is to overview on the detailed implications of the HLA-B*27 subtypes in 
      the etiopathogenesis of AS. Moreover, the role of ERAP1 in AS and its epistasis 
      with HLA-B*27 have been reviewed.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Dashti, Navid
AU  - Dashti N
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran; Department of Immunology, School of Medicine, TehranUniversity of Medical 
      Sciences, Tehran, Iran.
FAU - Mahmoudi, Mahdi
AU  - Mahmoudi M
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. Electronic address: mahmoudim@tums.ac.ir.
FAU - Aslani, Saeed
AU  - Aslani S
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran.
FAU - Jamshidi, Ahmadreza
AU  - Jamshidi A
AD  - Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. Electronic address: jamshida@tums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180524
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Humans
MH  - Spondylitis, Ankylosing/*genetics
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - ERAP, gene association
OT  - HLA-B*27
EDAT- 2018/05/29 06:00
MHDA- 2018/06/23 06:00
CRDT- 2018/05/27 06:00
PHST- 2018/03/05 00:00 [received]
PHST- 2018/05/14 00:00 [revised]
PHST- 2018/05/23 00:00 [accepted]
PHST- 2018/05/29 06:00 [pubmed]
PHST- 2018/06/23 06:00 [medline]
PHST- 2018/05/27 06:00 [entrez]
AID - S0378-1119(18)30589-4 [pii]
AID - 10.1016/j.gene.2018.05.092 [doi]
PST - ppublish
SO  - Gene. 2018 Sep 5;670:15-21. doi: 10.1016/j.gene.2018.05.092. Epub 2018 May 24.