PMID- 29805590
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 15
IP  - 6
DP  - 2018 Jun
TI  - Suppression of tumor cell proliferation and migration by human umbilical cord 
      mesenchymal stem cells: A possible role for apoptosis and Wnt signaling.
PG  - 8536-8544
LID - 10.3892/ol.2018.8368 [doi]
AB  - Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential 
      therapeutic tools for solid tumors. However, there are numerous inconsistent 
      results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying 
      this remain poorly understood. The present study further examined this 
      controversial issue by analyzing the molecular mechanisms of the inhibitory 
      effects of hUCMSCs on the proliferation and migration of the human lung cancer 
      A549 cell line and the human hepatocellular carcinoma (HCC) BEL7402 cell line in 
      vitro. Flow cytometric analysis demonstrated that hUCMSCs arrested tumor cells in 
      specific phases of the cell cycle and induced the apoptosis of tumor cells by 
      using the hUCMSC-conditioned medium (hUCMSC-CM). The hUCMSC-CM also attenuated 
      the migratory abilities of the two tumor cell types. Furthermore, the expression 
      of B-cell lymphoma 2 (Bcl-2), the pro-form of caspase-7 (pro-caspase-7), 
      beta-catenin and c-Myc was downregulated, while that of ephrin receptor (EphA5), a 
      biomarker of cancer cell dormancy, was slightly increased in these two tumor cell 
      lines treated with hUCMSC-CM. Specifically, when co-cultured via direct 
      cell-to-cell contact, hUCMSCs were able to spontaneously fuse with any of the two 
      types of solid tumor cells. These observations suggested that hUCMSCs may be a 
      promising candidate for the biological therapy of lung cancer and HCC. Future 
      studies should focus on detailed evidence for cell fusion, as well as other 
      mechanisms proposed in the present study, by introducing additional experimental 
      approaches and models.
FAU - Yuan, Yin
AU  - Yuan Y
AD  - School of Life Science and Biopharmacology, School of Anatomy and Histology, 
      Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, 
      Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China.
FAU - Zhou, Chang
AU  - Zhou C
AD  - School of Life Science and Biopharmacology, School of Anatomy and Histology, 
      Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, 
      Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China.
FAU - Chen, Xuan
AU  - Chen X
AD  - School of Life Science and Biopharmacology, School of Anatomy and Histology, 
      Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, 
      Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China.
FAU - Tao, Changli
AU  - Tao C
AD  - School of Life Science and Biopharmacology, School of Anatomy and Histology, 
      Guangdong Provincial Key Laboratory of Biotechnology Candidate Drug Research, 
      Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China.
FAU - Cheng, Huiqing
AU  - Cheng H
AD  - School of Life Science, South China Normal University, Guangzhou, Guangdong 
      510631, P.R. China.
FAU - Lu, Xin
AU  - Lu X
AD  - School of Life Science, South China Normal University, Guangzhou, Guangdong 
      510631, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180328
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5950566
OTO - NOTNLM
OT  - Wnt signaling
OT  - apoptosis
OT  - cell fusion
OT  - mesenchymal stem cells
OT  - tumor
EDAT- 2018/05/29 06:00
MHDA- 2018/05/29 06:01
PMCR- 2018/03/28
CRDT- 2018/05/29 06:00
PHST- 2017/09/23 00:00 [received]
PHST- 2018/02/28 00:00 [accepted]
PHST- 2018/05/29 06:00 [entrez]
PHST- 2018/05/29 06:00 [pubmed]
PHST- 2018/05/29 06:01 [medline]
PHST- 2018/03/28 00:00 [pmc-release]
AID - OL-0-0-8368 [pii]
AID - 10.3892/ol.2018.8368 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Jun;15(6):8536-8544. doi: 10.3892/ol.2018.8368. Epub 2018 Mar 
      28.