PMID- 2982354
OWN - NLM
STAT- MEDLINE
DCOM- 19850314
LR  - 20190815
IS  - 0304-8608 (Print)
IS  - 0304-8608 (Linking)
VI  - 83
IP  - 3-4
DP  - 1985
TI  - Natural infection of Swiss mice with mouse mammary tumor virus (MMTV): viral 
      expression in milk and transmission of infection.
PG  - 195-206
AB  - Quantitative determinations of gp52, the main envelope glycoprotein, and p28, the 
      main core protein, of MMTV, have been performed in about 1000 individual samples 
      of milk of breeding females from our colony of MMTV-infected Swiss mice, a line 
      characterized by a moderate incidence of mammary tumors. A computer analysis of 
      the results showed: 1-- an important individual variation, ranging from 0 to 120 
      micrograms per ml of milk for p28, and from 0 to 320 micrograms per ml of milk 
      for gp52; 2-- a variation of the release of both antigens during a single 
      lactation, with a maximum on the 7--8th day of nursing; 3-- an increase of the 
      release of both antigens with parity up to the 6th lactation, followed by a 
      marked decrease during later lactations; 4-- a higher degree of infection in the 
      offspring of 2nd and 3rd litters. The possible dependence of viral expression and 
      transmission of infection upon factors such as cyclic activity of the mammary 
      gland and progressive immunization of mice against MMTV is analyzed. The status 
      of our laboratory line of MMTV infected Swiss mice is discussed in comparison 
      with high and low tumor incidence strains.
FAU - Hainaut, P
AU  - Hainaut P
FAU - Vaira, D
AU  - Vaira D
FAU - Francois, C
AU  - Francois C
FAU - Calberg-Bacq, C M
AU  - Calberg-Bacq CM
FAU - Osterrieth, P M
AU  - Osterrieth PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - Arch Virol
JT  - Archives of virology
JID - 7506870
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Viral)
RN  - 0 (Antigens, Viral, Tumor)
RN  - 0 (glycoprotein 52 antigen, Mouse mammary tumor virus)
SB  - IM
MH  - Animals
MH  - Antigens, Neoplasm/analysis
MH  - Antigens, Viral/analysis
MH  - *Antigens, Viral, Tumor
MH  - Female
MH  - *Lactation
MH  - Mammary Neoplasms, Experimental/*transmission
MH  - *Mammary Tumor Virus, Mouse/immunology
MH  - Mice
MH  - Milk/immunology/*microbiology
MH  - Parity
MH  - Pregnancy
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1007/BF01309916 [doi]
PST - ppublish
SO  - Arch Virol. 1985;83(3-4):195-206. doi: 10.1007/BF01309916.