PMID- 2982729 OWN - NLM STAT- MEDLINE DCOM- 19850328 LR - 20181113 IS - 0019-2805 (Print) IS - 1365-2567 (Electronic) IS - 0019-2805 (Linking) VI - 54 IP - 1 DP - 1985 Jan TI - Inhibition by human T-lymphotropic virus (HTLV-I) of T-lymphocyte mitogenesis: failure of exogenous T-cell growth factor to restore responsiveness to lectin. PG - 1-7 AB - Various retroviruses, including human T-cell lymphotropic virus (HTLV-I) and avian sarcoma virus (ASV), can prevent coincubated human peripheral lymphocytes from responding efficiently to phytohaemagglutinin. Addition of high concentrations of T-cell growth factor (TCGF) activity usually overcomes this inhibition. However, such restoration of responsiveness does not occur in the case of HTLV-coincubated cells. FAU - Wainberg, M A AU - Wainberg MA FAU - Spira, B AU - Spira B FAU - Boushira, M AU - Boushira M FAU - Margolese, R G AU - Margolese RG LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Immunology JT - Immunology JID - 0374672 RN - 0 (Interleukin-2) RN - 0 (Phytohemagglutinins) SB - IM MH - Avian Sarcoma Viruses/immunology MH - Deltaretrovirus/*immunology MH - Humans MH - Interleukin-2/*immunology MH - *Lymphocyte Activation MH - Phytohemagglutinins/pharmacology MH - T-Lymphocytes/*immunology PMC - PMC1454845 EDAT- 1985/01/01 00:00 MHDA- 1985/01/01 00:01 PMCR- 1986/01/01 CRDT- 1985/01/01 00:00 PHST- 1985/01/01 00:00 [pubmed] PHST- 1985/01/01 00:01 [medline] PHST- 1985/01/01 00:00 [entrez] PHST- 1986/01/01 00:00 [pmc-release] PST - ppublish SO - Immunology. 1985 Jan;54(1):1-7.