PMID- 29843044
OWN - NLM
STAT- MEDLINE
DCOM- 20181031
LR  - 20200930
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 105
DP  - 2018 Sep
TI  - The antidepressant-like effects of Chaihu Shugan San: Dependent on the 
      hippocampal BDNF-TrkB-ERK/Akt signaling activation in perimenopausal 
      depression-like rats.
PG  - 45-52
LID - S0753-3322(18)30369-X [pii]
LID - 10.1016/j.biopha.2018.04.035 [doi]
AB  - Chaihu Shugan San (CSS), a traditional Chinese medicine formula, has been used to 
      treat depression for hundreds of years. Recently, the antidepressant-like 
      mechanism of CSS has been increasingly evaluated and demonstrated. However, there 
      are few studies focused on the involvement of the neurotrophic system in 
      mediating the antidepressant-like effects of CSS. Considering the high prevalence 
      of perimenopausal depression around the world, the goal of the present study was 
      to determine whether brain-derived neurotrophic factor (BDNF) signaling is 
      required for the antidepressant-like effects of CSS in perimenopausal 
      depressive-like rats. The results indicate that CSS reverses depressive-like 
      behaviors and attenuates the downregulation of BDNF in the hippocampus of 
      perimenopausal rats exposed to chronic unpredictable mild stress (CUMS). We found 
      that the TrkB antagonist K252 not only blocks the effects of CSS on behavioral 
      improvement but also abolishes the activation of CSS in BDNF-TrkB signaling. As a 
      result, the downstream targets of BDNF signaling, such as the ERK and Akt 
      pathways, are significantly inhibited by K252a. Furthermore, CSS increases 
      hippocampal neurogenesis, while K252a fully prevents this action. In conclusion, 
      the present results demonstrate that the activation of the hippocampal 
      BDNF-TrkB-ERK/Akt signaling pathway is required for the antidepressant-like 
      effects of CSS on the depressive-like state during perimenopause. Additionally, 
      this study also demonstrates that neurogenesis is required for the effects of 
      antidepressants in aging perimenopausal animals and provides fundamental evidence 
      for the clinical application of CSS.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Chen, Xue-Qin
AU  - Chen XQ
AD  - Xiamen Hospital of Traditional Chinese Medicine affiliated to Fujian University 
      of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China; 
      Research base of TCM syndrome, Fujian University of Traditional Chinese Medicine, 
      Fuzhou 350108, Fujian province, PR China.
FAU - Li, Cheng-Fu
AU  - Li CF
AD  - Xiamen Hospital of Traditional Chinese Medicine affiliated to Fujian University 
      of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China.
FAU - Chen, Shu-Jiao
AU  - Chen SJ
AD  - The Third Hospital affiliated to Fujian University of Traditional Chinese 
      Medicine, Fuzhou 350108, Fujian province, PR China.
FAU - Liang, Wen-Na
AU  - Liang WN
AD  - Research base of TCM syndrome, Fujian University of Traditional Chinese Medicine, 
      Fuzhou 350108, Fujian province, PR China.
FAU - Wang, Miao
AU  - Wang M
AD  - Research base of TCM syndrome, Fujian University of Traditional Chinese Medicine, 
      Fuzhou 350108, Fujian province, PR China.
FAU - Wang, Shuang-Shuang
AU  - Wang SS
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
FAU - Dong, Shu-Qi
AU  - Dong SQ
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
FAU - Yi, Li-Tao
AU  - Yi LT
AD  - Department of Chemical and Pharmaceutical Engineering, College of Chemical 
      Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China. 
      Electronic address: litaoyi@hqu.edu.cn.
FAU - Li, Can-Dong
AU  - Li CD
AD  - Research base of TCM syndrome, Fujian University of Traditional Chinese Medicine, 
      Fuzhou 350108, Fujian province, PR China. Electronic address: fjzylcd@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180526
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 0 (chaihu-shugan-san)
RN  - EC 2.7.10.1 (Ntrk2 protein, rat)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Depression/*drug therapy/metabolism
MH  - Disease Models, Animal
MH  - *Estrous Cycle
MH  - Female
MH  - Hippocampus/*drug effects/metabolism
MH  - MAP Kinase Signaling System/drug effects
MH  - Plant Extracts/*therapeutic use
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - Rats, Wistar
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/*drug effects
MH  - Stress, Psychological/drug therapy/metabolism
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor (BDNF)
OT  - Chaihu Shugan San (CSS)
OT  - Chronic unpredictable mild stress (CUMS)
OT  - Perimenopausal depression
EDAT- 2018/05/31 06:00
MHDA- 2018/11/01 06:00
CRDT- 2018/05/30 06:00
PHST- 2018/01/17 00:00 [received]
PHST- 2018/04/04 00:00 [revised]
PHST- 2018/04/05 00:00 [accepted]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2018/11/01 06:00 [medline]
PHST- 2018/05/30 06:00 [entrez]
AID - S0753-3322(18)30369-X [pii]
AID - 10.1016/j.biopha.2018.04.035 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2018 Sep;105:45-52. doi: 10.1016/j.biopha.2018.04.035. Epub 
      2018 May 26.