PMID- 29843098
OWN - NLM
STAT- MEDLINE
DCOM- 20181009
LR  - 20181009
IS  - 1873-264X (Electronic)
IS  - 0731-7085 (Linking)
VI  - 157
DP  - 2018 Aug 5
TI  - Determination of phenolic acids in extra virgin olive oil using supercritical 
      fluid chromatography coupled with single quadrupole mass spectrometry.
PG  - 217-225
LID - S0731-7085(18)30702-7 [pii]
LID - 10.1016/j.jpba.2018.05.025 [doi]
AB  - Phenolic acids represent one third of the total phenolic compounds in extra 
      virgin olive oil (EVOO) and contribute greatly to the biological and sensory 
      properties of EVOO. In the present research, an analytical method based on 
      supercritical fluid chromatography coupled with single quadrupole mass 
      spectrometry (SFC-MS) was developed for the analysis of phenolic acids in EVOOs. 
      The chromatographic and MS conditions were optimized in terms of selectivity, 
      peak shape and sensitivity. Satisfactory separation of 12 phenolic acids was 
      achieved within 20 min on a Platisil CN column (250 mm x 4.6 mm, 5 mum) using 7% 
      (v/v) water and 0.5% (v/v) formic acid in MeOH as mobile phase additives at the 
      backpressure of 140 bar and temperature of 60  degrees C. The developed method was 
      validated by evaluating the linearity, sensitivity, repeatability, intermediate 
      precision and accuracy. The limits of detection (LODs) and limits of 
      quantification (LOQs) of the SFC-MS method for phenolic acids ranged from 0.03 to 
      5.00 mug/mL and 0.08 to 15.0 mug/mL, respectively. The relative standard deviations 
      (RSDs) for intraday and interday precision were lower than 9.91% and the 
      recoveries ranged from 80.2 to 117% and 80.9 to 118% for low-level and high-level 
      concentrations of standards spiked in olive oil, respectively. Compared to an 
      HPLC method, the SFC method was about three times faster and provided better 
      selectivity. Finally, the SFC-MS method was successfully employed for the 
      quantitative analysis of phenolic acids in EVOOs. Differences in individual and 
      total phenolic acid contents were observed between six varieties.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Tang, Guangyun
AU  - Tang G
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China.
FAU - Huang, Yang
AU  - Huang Y
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China; Laboratory for the Analysis of Medicines, Department of 
      Pharmaceutical Sciences, CIRM, University of Liege, Avenue Hippocrate 15, 4000 
      Liege, Belgium.
FAU - Zhang, Tingting
AU  - Zhang T
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China.
FAU - Wang, Qiqin
AU  - Wang Q
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China.
FAU - Crommen, Jacques
AU  - Crommen J
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China; Laboratory for the Analysis of Medicines, Department of 
      Pharmaceutical Sciences, CIRM, University of Liege, Avenue Hippocrate 15, 4000 
      Liege, Belgium.
FAU - Fillet, Marianne
AU  - Fillet M
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China; Laboratory for the Analysis of Medicines, Department of 
      Pharmaceutical Sciences, CIRM, University of Liege, Avenue Hippocrate 15, 4000 
      Liege, Belgium.
FAU - Jiang, Zhengjin
AU  - Jiang Z
AD  - Institute of Pharmaceutical Analysis, College of Pharmacy, Jinan University, 
      Guangzhou 510632, China; Guangdong Province Key Laboratory of Pharmacodynamic 
      Constituents of Traditional Chinese Medicine & New Drug Research, Jinan 
      University, Guangzhou 510632, China. Electronic address: 
      jiangzhengjin@jnu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20180518
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Hydroxybenzoates)
RN  - 0 (Olive Oil)
RN  - 0 (Phenols)
RN  - I3P9R8317T (phenolic acid)
SB  - IM
MH  - Chromatography, High Pressure Liquid/methods
MH  - Chromatography, Supercritical Fluid/methods
MH  - Hydroxybenzoates/*chemistry
MH  - Limit of Detection
MH  - Olive Oil/*chemistry
MH  - Phenols/chemistry
MH  - Sensitivity and Specificity
MH  - Tandem Mass Spectrometry/methods
OTO - NOTNLM
OT  - Extra virgin olive oils
OT  - Phenolic acids
OT  - Supercritical fluid chromatography
EDAT- 2018/05/31 06:00
MHDA- 2018/10/10 06:00
CRDT- 2018/05/30 06:00
PHST- 2018/03/25 00:00 [received]
PHST- 2018/05/16 00:00 [revised]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2018/10/10 06:00 [medline]
PHST- 2018/05/30 06:00 [entrez]
AID - S0731-7085(18)30702-7 [pii]
AID - 10.1016/j.jpba.2018.05.025 [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 2018 Aug 5;157:217-225. doi: 10.1016/j.jpba.2018.05.025. 
      Epub 2018 May 18.