PMID- 29843238
OWN - NLM
STAT- MEDLINE
DCOM- 20190610
LR  - 20190613
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 63
IP  - 4
DP  - 2018
TI  - Oxidative Stress in Elderly with Different Cognitive Status: My Mind Project.
PG  - 1405-1414
LID - 10.3233/JAD-171117 [doi]
AB  - BACKGROUND: Biomarkers of oxidative stress have been associated with cognitive 
      status in humans and have been proposed to guide prognosis/treatment in 
      Alzheimer's disease (AD) and mild cognitive impairment (MCI). OBJECTIVE: The aim 
      of this study was to compare oxidative stress status in the plasma of 
      mild-moderate AD, MCI, and healthy elderly with normal cognition (HE) undergoing 
      a non-pharmacological intervention including multi-modal cognitive training ("My 
      Mind Project"). METHODS: A prospective randomized trial involving 321 elderly 
      people enrolled in Marche Region, Italy. Each subject was randomly assigned to an 
      experimental (cognitive training) or to a control group. Cognitive performances 
      and biomarkers have been analyzed before intervention (baseline), immediately 
      after termination (follow-up 1), after 6 months (follow-up 2), and after 2 years 
      (follow-up 3). The biological antioxidant potential (BAP) to Diacron reactive 
      oxygen metabolites (d-ROM) ratio has been used as an indicator of oxidative 
      stress status and as outcome variable. RESULTS: We have found no differences in 
      the oxidative status among AD, MCI, and HE. Neither did we find a significant 
      effect of the intervention within experimental groups. Gender was the sole factor 
      with a strong significant effect on BAP/d-ROM. CONCLUSIONS: Based on these 
      results, the utility of biomarkers of oxidative stress to guide 
      prognosis/treatment in AD or MCI seems to be limited by lack of specificity, 
      large interindividual variability, and gender bias.
FAU - Fattoretti, Patrizia
AU  - Fattoretti P
AD  - Cellular Bioenergetics Laboratory, Center for Neurobiology of Aging, INRCA-IRCCS, 
      Ancona, Italy.
FAU - Malavolta, Marco
AU  - Malavolta M
AD  - Advanced Technology Center for Aging Research, INRCA-IRCCS, Ancona, Italy.
FAU - Fabbietti, Paolo
AU  - Fabbietti P
AD  - Unit of Geriatric Pharmacoepidemiology, INRCA-IRCCS, Cosenza, Italy.
FAU - Papa, Roberta
AU  - Papa R
AD  - Centre of Socio-Economic Gerontological Research, INRCA-IRCCS, Ancona, Italy.
FAU - Giacconi, Robertina
AU  - Giacconi R
AD  - Advanced Technology Center for Aging Research, INRCA-IRCCS, Ancona, Italy.
FAU - Costarelli, Laura
AU  - Costarelli L
AD  - Clinical Laboratory and Molecular Diagnostics, INRCA-IRCCS, Ancona, Italy.
FAU - Galeazzi, Roberta
AU  - Galeazzi R
AD  - Clinical Laboratory and Molecular Diagnostics, INRCA-IRCCS, Ancona, Italy.
FAU - Paoloni, Cristina
AU  - Paoloni C
AD  - Geriatrics Operative Unit, INRCA-IRCCS, Fermo, Italy.
FAU - Postacchini, Demetrio
AU  - Postacchini D
AD  - Geriatrics Operative Unit, INRCA-IRCCS, Fermo, Italy.
FAU - Lattanzio, Fabrizia
AU  - Lattanzio F
AD  - Scientific Direction, INRCA-IRCCS, Ancona, Italy.
FAU - Giuli, Cinzia
AU  - Giuli C
AD  - Geriatrics Operative Unit, INRCA-IRCCS, Fermo, Italy.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Biomarkers)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Aged
MH  - *Aging
MH  - Alzheimer Disease/*physiopathology/rehabilitation
MH  - Biomarkers/blood
MH  - Cognitive Behavioral Therapy
MH  - Cognitive Dysfunction/*physiopathology/rehabilitation
MH  - Female
MH  - Humans
MH  - Italy
MH  - Longitudinal Studies
MH  - Male
MH  - Neuropsychological Tests
MH  - Oxidative Stress/*physiology
MH  - Prospective Studies
MH  - Reactive Oxygen Species/blood
OTO - NOTNLM
OT  - Aging
OT  - Alzheimer's disease
OT  - cognitive dysfunction
OT  - oxidative stress
EDAT- 2018/05/31 06:00
MHDA- 2019/06/14 06:00
CRDT- 2018/05/31 06:00
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2019/06/14 06:00 [medline]
PHST- 2018/05/31 06:00 [entrez]
AID - JAD171117 [pii]
AID - 10.3233/JAD-171117 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2018;63(4):1405-1414. doi: 10.3233/JAD-171117.