PMID- 29843618
OWN - NLM
STAT- MEDLINE
DCOM- 20190314
LR  - 20240326
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 18
IP  - 1
DP  - 2018 May 29
TI  - Plasma levels of free fatty acid differ in patients with left ventricular 
      preserved, mid-range, and reduced ejection fraction.
PG  - 104
LID - 10.1186/s12872-018-0850-0 [doi]
LID - 104
AB  - BACKGROUND: Free fatty acids (FFAs) predicted the risk of heart failure (HF) and 
      were elevated in HF with very low left ventricular ejection fraction (LVEF) 
      compared to healthy subjects. The aim of this study was to investigate whether 
      total levels of FFA in plasma differed in patients with HF with preserved 
      (HFpEF), mid-range (HFmrEF), and reduced ejection fraction (HFrEF) and the 
      association with the three categories. METHODS: One hundred thirty-nine patients 
      with HFpEF, HFmrEF and HFrEF were investigated in this study. Plasma FFA levels 
      were measured using commercially available assay kits, and LVEF was calculated by 
      echocardiography with the Simpson biplane method. Dyspnea ranked by New York 
      Heart Association (NYHA) was also identified. RESULTS: FFA concentrations were 
      higher in HFrEF than in HFmrEF and HFpEF, respectively (689 +/- 321.5 mumol/L vs. 
      537.9 +/- 221.6 mumol/L, p = 0.036; 689 +/- 321.5 mumol/L vs. 527.5 +/- 185.5 mumol/L, 
      p = 0.008). No significant differences in FFA levels were found between HFmrEF 
      and HFpEF (537.9 +/- 221.6 mumol/L vs. 527.5 +/- 185.5 mumol/L, p = 0.619). In 
      addition, we found a negative correlation between FFA levels and LVEF (regression 
      coefficient: - 0.229, p = 0.004) and a positive correlation between FFAs and NYHA 
      class (regression coefficient: 0.214, p = 0.014) after adjustment for clinical 
      characteristic, medical history and therapies. ROC analysis revealed that FFAs 
      predicted HFrEF across the three categories (AUC: 0.644, p = 0.005) and the 
      optimal cut-off level to predict HFrEF was FFA levels above 575 mumol/L. 
      CONCLUSIONS: FFA levels differed across the three categories, which suggests that 
      energy metabolism differs between HFpEF, HFmrEF and HFrEF.
FAU - Zhu, Ning
AU  - Zhu N
AUID- ORCID: 0000-0002-7521-6266
AD  - Department of Cardiology, The Third Clinical College of Wenzhou Medical 
      University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, 
      Zhejiang Province, People's Republic of China. zhuningccc@126.com.
FAU - Jiang, Wenbing
AU  - Jiang W
AD  - Department of Cardiology, The Third Clinical College of Wenzhou Medical 
      University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, 
      Zhejiang Province, People's Republic of China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Department of Cardiology, The Third Clinical College of Wenzhou Medical 
      University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, 
      Zhejiang Province, People's Republic of China.
FAU - Wu, Youyang
AU  - Wu Y
AD  - Department of Cardiology, The Third Clinical College of Wenzhou Medical 
      University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, 
      Zhejiang Province, People's Republic of China.
FAU - Chen, Hao
AU  - Chen H
AD  - Department of Cardiology, The Third Clinical College of Wenzhou Medical 
      University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, 
      Zhejiang Province, People's Republic of China.
FAU - Zhao, Xuyong
AU  - Zhao X
AD  - Department of Cardiology, The Third Clinical College of Wenzhou Medical 
      University, Wenzhou People's Hospital, No. 57 Canghou Street, Wenzhou, 325000, 
      Zhejiang Province, People's Republic of China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20180529
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids, Nonesterified)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Blood Pressure
MH  - *Energy Metabolism
MH  - Fatty Acids, Nonesterified/*blood
MH  - Female
MH  - Heart Failure/*blood/diagnosis/physiopathology
MH  - Humans
MH  - Hypertension/blood/physiopathology
MH  - Male
MH  - Pilot Projects
MH  - *Stroke Volume
MH  - Up-Regulation
MH  - *Ventricular Function, Left
PMC - PMC5975423
OTO - NOTNLM
OT  - Free fatty acid
OT  - Heart failure
OT  - Mid-range ejection fraction
OT  - Preserved ejection fraction
OT  - Reduced ejection fraction
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: The ethics committee of Wenzhou 
      People's Hospital approved the study. Written informed consent was obtained from 
      the parents of all of the participants. COMPETING INTERESTS: The authors report 
      no relationships that could be construed as a conflict of interest. PUBLISHER'S 
      NOTE: Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2018/05/31 06:00
MHDA- 2019/03/15 06:00
PMCR- 2018/05/29
CRDT- 2018/05/31 06:00
PHST- 2018/02/16 00:00 [received]
PHST- 2018/05/25 00:00 [accepted]
PHST- 2018/05/31 06:00 [entrez]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2019/03/15 06:00 [medline]
PHST- 2018/05/29 00:00 [pmc-release]
AID - 10.1186/s12872-018-0850-0 [pii]
AID - 850 [pii]
AID - 10.1186/s12872-018-0850-0 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2018 May 29;18(1):104. doi: 10.1186/s12872-018-0850-0.