PMID- 29844379
OWN - NLM
STAT- MEDLINE
DCOM- 20191104
LR  - 20191104
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 May 29
TI  - Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in 
      individuals exposed to Plasmodium vivax.
PG  - 8347
LID - 10.1038/s41598-018-26677-x [doi]
LID - 8347
AB  - The major challenge in designing a protective Duffy binding protein region II 
      (DBPII)-based vaccine against blood-stage vivax malaria is the high number of 
      polymorphisms in critical residues targeted by binding-inhibitory antibodies. 
      Here, longevity of antibody and memory B cell response (MBCs) to DBL-TH variants, 
      DBL-TH2, -TH4, -TH5, -TH6 and -TH9 were analyzed in P. vivax-exposed individuals 
      living in a low malaria transmission area of southern Thailand. Antibody to 
      DBL-TH variants were significantly detected during P. vivax infection and it was 
      persisted for up to 9 months post-infection. However, DBL-TH-specific MBC 
      responses were stably maintained longer than antibody response, at least 3 years 
      post-infection in the absence of re-infection. Phenotyping of B cell subsets 
      showed the expansion of activated and atypical MBCs during acute and recovery 
      phase of infection. While the persistence of DBL-TH-specific MBCs was found in 
      individuals who had activated and atypical MBC expansion, anti-DBL-TH antibody 
      responses was rapidly declined in plasma. The data suggested that these two MBCs 
      were triggered by P. vivax infection, its expansion and stability may have impact 
      on antibody responses. Our results provided evidence for ability of DBPII variant 
      antigens in induction of long-lasting MBCs among individuals who were living in 
      low malaria endemicity.
FAU - Changrob, Siriruk
AU  - Changrob S
AD  - Department of Clinical Microbiology and Applied Technology, Faculty of Medical 
      Technology, Mahidol University, Bangkok, 10700, Thailand.
FAU - McHenry, Amy M
AU  - McHenry AM
AD  - Department of Biological Sciences, Southwestern Adventist University, Keene, 
      Texas, 76059, USA.
FAU - Nyunt, Myat Htut
AU  - Nyunt MH
AUID- ORCID: 0000-0002-2026-8026
AD  - Department of Medical Environmental Biology and Tropical Medicine, School of 
      Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic 
      of Korea.
FAU - Sattabongkot, Jetsumon
AU  - Sattabongkot J
AD  - Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, 
      Bangkok, 10400, Thailand.
FAU - Han, Eun-Taek
AU  - Han ET
AD  - Department of Medical Environmental Biology and Tropical Medicine, School of 
      Medicine, Kangwon National University, Chuncheon, Gangwon-do, 200-701, Republic 
      of Korea.
FAU - Adams, John H
AU  - Adams JH
AUID- ORCID: 0000-0003-3707-7979
AD  - Department of Global Health, University of South Florida, Tampa, Florida, 33612, 
      USA.
FAU - Chootong, Patchanee
AU  - Chootong P
AD  - Department of Clinical Microbiology and Applied Technology, Faculty of Medical 
      Technology, Mahidol University, Bangkok, 10700, Thailand. pchooton@gmail.com.
LA  - eng
GR  - R01 AI064478/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180529
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Antibodies, Protozoan)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Malaria Vaccines)
RN  - 0 (Protozoan Proteins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Protozoan/immunology
MH  - Antibody Formation/immunology
MH  - B-Lymphocytes/*immunology/metabolism
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Duffy Blood-Group System
MH  - Female
MH  - Humans
MH  - Immunity, Humoral/physiology
MH  - Malaria/blood
MH  - Malaria Vaccines/*immunology
MH  - Malaria, Vivax/*immunology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Plasmodium vivax/genetics/immunology
MH  - Polymorphism, Genetic/genetics
MH  - Protozoan Proteins/genetics
MH  - Receptors, Cell Surface/genetics
PMC - PMC5973932
COIS- The authors declare no competing interests.
EDAT- 2018/05/31 06:00
MHDA- 2019/11/05 06:00
PMCR- 2018/05/29
CRDT- 2018/05/31 06:00
PHST- 2018/01/06 00:00 [received]
PHST- 2018/05/17 00:00 [accepted]
PHST- 2018/05/31 06:00 [entrez]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2019/11/05 06:00 [medline]
PHST- 2018/05/29 00:00 [pmc-release]
AID - 10.1038/s41598-018-26677-x [pii]
AID - 26677 [pii]
AID - 10.1038/s41598-018-26677-x [doi]
PST - epublish
SO  - Sci Rep. 2018 May 29;8(1):8347. doi: 10.1038/s41598-018-26677-x.