PMID- 29845063
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1728-3043 (Print)
IS  - 2322-2921 (Electronic)
IS  - 1728-3043 (Linking)
VI  - 15
IP  - 3
DP  - 2017
TI  - Bone Marrow Stromal Cells Associated with Poly L-Lactic-Co-Glycolic Acid (PLGA) 
      Nanofiber Scaffold Improve Transected Sciatic Nerve Regeneration.
PG  - 149-156
LID - 10.15171/ijb.1576 [doi]
AB  - Background: Although peripheral nerves show capacity for regeneration after 
      injury to a certain extent, the extent of regeneration is not remarkable. 
      Previous studies have suggested that through the production of growth factors or 
      extracellular matrix components, mesenchymal stem cells may enhance nerve 
      regeneration. Objectives: In the present study, the therapeutic potency of the 
      Bone Marrow Stromal Cells (BMSCs) associated with Poly L-lactic-co-glycolic acid 
      (PLGA) nanofiber Scaffolds on rat sciatic nerve repair was evaluated. Material 
      and Methods: Thirty adult male Wistar rats (220-250 g) were divided randomly into 
      six groups, including control 1 (transected sciatic nerve), control 2 (transected 
      sciatic nerve and stitched), Sham, PLGA, BMSCs, and PLGA+BMSCs. Functional 
      recovery was evaluated at the end of 2(nd), 4(th), 6(th), and 8(th) weeks after 
      surgery using sciatic functional index (SFI) and hot water test. After killing 
      all rats at the end of 8(th) week, their sciatic nerves were removed, fixed, and 
      processed for the histological examination and analysis by the Motic software. 
      Results: A significant recovery of the sciatic nerve function was observed in the 
      PLGA+BMSCs transplanted group at the 8th week after surgery as demonstrated by 
      SFI and hot water findings. Histological examinations also showed a significant 
      improvement in the PLGA+BMSCs group compared to the control 1, 2, Sham, PLGA and 
      BMSCs groups. Conclusion: BMSCs associated with PLGA nanofiber scaffold might be 
      useful for improving the functional peripheral nerve repair having some clinical 
      outcome.
FAU - Kaka, Gholamreza
AU  - Kaka G
AD  - Neuroscience Research Center, Baqiyatallah University of Medical Sciences, 
      Tehran, Iran.
FAU - Arum, Jamshid
AU  - Arum J
AD  - Neuroscience Research Center, Baqiyatallah University of Medical Sciences, 
      Tehran, Iran.
FAU - Sadraie, Seyed Homayoon
AU  - Sadraie SH
AD  - Neuroscience Research Center, Baqiyatallah University of Medical Sciences, 
      Tehran, Iran.
AD  - Department of Anatomy, School of Medicine, Baqiyatallah University of Medical 
      Sciences, Tehran, Iran.
FAU - Emamgholi, Asgar
AU  - Emamgholi A
AD  - Neuroscience Research Center, Baqiyatallah University of Medical Sciences, 
      Tehran, Iran.
FAU - Mohammadi, Alireza
AU  - Mohammadi A
AD  - Neuroscience Research Center, Baqiyatallah University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - Iran
TA  - Iran J Biotechnol
JT  - Iranian journal of biotechnology
JID - 101276796
PMC - PMC5811061
OTO - NOTNLM
OT  - Poly L-lactic-co-glycolic acid (PLGA)
OT  - Repair
OT  - Scaffold
OT  - Sciatic nerve
EDAT- 2018/05/31 06:00
MHDA- 2018/05/31 06:01
PMCR- 2017/09/27
CRDT- 2018/05/31 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/09/26 00:00 [revised]
PHST- 2017/06/20 00:00 [accepted]
PHST- 2018/05/31 06:00 [entrez]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2018/05/31 06:01 [medline]
PHST- 2017/09/27 00:00 [pmc-release]
AID - 10.15171/ijb.1576 [doi]
PST - epublish
SO  - Iran J Biotechnol. 2017 Sep 27;15(3):149-156. doi: 10.15171/ijb.1576. eCollection 
      2017.