PMID- 29845269
OWN - NLM
STAT- MEDLINE
DCOM- 20181113
LR  - 20181113
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Jul
TI  - Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury 
      (Review).
PG  - 675-683
LID - 10.3892/mmr.2018.9028 [doi]
AB  - Autophagy is a maintenance process for recycling long-lived proteins and 
      cytoplasmic organelles. The level of this process is enhanced during 
      ischemia/reperfusion (I/R) injury. Autophagy can trigger survival signaling in 
      myocardial ischemia, whereas defective autophagy during reperfusion is 
      detrimental. Autophagy can be regulated through multiple signaling pathways in 
      I/R, including Beclin‑1/class III phosphatidylinositol‑3 kinase (PI‑3K), 
      adenosine monophosphate activated protein kinase/mammalian target of rapamycin 
      (mTOR), and PI‑3K/protein kinase B/mTOR pathways, which consequently lead to 
      different functions. Thus, autophagy has both protective and detrimental 
      functions, which are determined by different signaling pathways and conditions. 
      Targeting the activation of autophagy can be a promising new therapeutic strategy 
      for treating cardiovascular disease.
FAU - Lin, Xiao-Long
AU  - Lin XL
AD  - Department of Pathology, Hui Zhou Third People's Hospital, Guangzhou Medical 
      University, Huizhou, Guangdong 516002, P.R. China.
FAU - Xiao, Wei-Jin
AU  - Xiao WJ
AD  - Department of Pathology, The Central Hospital of Shaoyang, Hunan 422000, P.R. 
      China.
FAU - Xiao, Le-Le
AU  - Xiao LL
AD  - School of Medicine, Huzhou University, Huzhou, Zhejiang 313000, P.R. China.
FAU - Liu, Mi-Hua
AU  - Liu MH
AD  - Department of Infectious Diseases, Centre for Lipid Research and Key Laboratory 
      of Molecular Biology for Infectious Diseases (Ministry of Education), Institute 
      for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical 
      University, Chongqing 400016, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180516
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
SB  - IM
MH  - Animals
MH  - *Autophagy
MH  - Humans
MH  - Myocardial Reperfusion Injury/metabolism/*physiopathology
MH  - *Signal Transduction
EDAT- 2018/05/31 06:00
MHDA- 2018/11/14 06:00
CRDT- 2018/05/31 06:00
PHST- 2017/11/17 00:00 [received]
PHST- 2018/05/10 00:00 [accepted]
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2018/11/14 06:00 [medline]
PHST- 2018/05/31 06:00 [entrez]
AID - 10.3892/mmr.2018.9028 [doi]
PST - ppublish
SO  - Mol Med Rep. 2018 Jul;18(1):675-683. doi: 10.3892/mmr.2018.9028. Epub 2018 May 
      16.