PMID- 29846197
OWN - NLM
STAT- MEDLINE
DCOM- 20190520
LR  - 20190520
IS  - 1531-7013 (Electronic)
IS  - 1087-2418 (Linking)
VI  - 23
IP  - 4
DP  - 2018 Aug
TI  - How the definition of acceptable antigens and epitope analysis can facilitate 
      transplantation of highly sensitized patients with excellent long-term graft 
      survival.
PG  - 493-499
LID - 10.1097/MOT.0000000000000545 [doi]
AB  - PURPOSE OF REVIEW: Highly sensitized patients awaiting a renal transplant have a 
      low chance of receiving an organ offer. Defining acceptable antigens and using 
      this information for allocation purposes can vastly enhance transplantation of 
      this subgroup of patients, which is the essence of the Eurotransplant Acceptable 
      Mismatch program. Acceptable antigens can be determined by extensive laboratory 
      testing, as well as on basis of human leukocyte antigen (HLA) epitope analyses. 
      RECENT FINDINGS: Within the Acceptable Mismatch program, there is no effect of 
      HLA mismatches on long-term graft survival. Furthermore, patients transplanted 
      through the Acceptable Mismatch program have similar long-term graft survival to 
      nonsensitized patients transplanted through regular allocation. Although HLA 
      epitope analysis is already being used for defining acceptable HLA antigens for 
      highly sensitized patients in the Acceptable Mismatch program, increasing 
      knowledge on HLA antibody - epitope interactions will pave the way toward the 
      definition of acceptable epitopes for highly sensitized patients in the future. 
      SUMMARY: Allocation based on acceptable antigens can facilitate transplantation 
      of highly sensitized patients with excellent long-term graft survival.
FAU - Heidt, Sebastiaan
AU  - Heidt S
AD  - Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, 
      The Netherlands.
FAU - Haasnoot, Geert W
AU  - Haasnoot GW
FAU - Claas, Frans H J
AU  - Claas FHJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Organ Transplant
JT  - Current opinion in organ transplantation
JID - 9717388
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Epitopes/*immunology
MH  - Graft Survival/immunology
MH  - HLA Antigens/*immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Kidney Transplantation/*methods
MH  - Tissue Donors
MH  - Transplantation Immunology
EDAT- 2018/05/31 06:00
MHDA- 2019/05/21 06:00
CRDT- 2018/05/31 06:00
PHST- 2018/05/31 06:00 [pubmed]
PHST- 2019/05/21 06:00 [medline]
PHST- 2018/05/31 06:00 [entrez]
AID - 10.1097/MOT.0000000000000545 [doi]
PST - ppublish
SO  - Curr Opin Organ Transplant. 2018 Aug;23(4):493-499. doi: 
      10.1097/MOT.0000000000000545.