PMID- 29848923
OWN - NLM
STAT- MEDLINE
DCOM- 20190523
LR  - 20190523
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 19
IP  - 6
DP  - 2018 Jun
TI  - Speckle-tracking strain assessment of left ventricular dysfunction in synthetic 
      cannabinoid and heroin users.
PG  - 388-393
LID - 10.14744/AnatolJCardiol.2018.76429 [doi]
AB  - OBJECTIVE: There is growing evidence regarding the numerous adverse effects of 
      synthetic cannabinoids (SCBs) on the cardiovascular system; however, no studies 
      have shown the cardiovascular effects of opioids using strain echocardiography. 
      This study examines the cardiac structure and function using echocardiographic 
      strain imaging in heroin and synthetic cannabinoid users. METHODS: This 
      double-blind study included patients who were admitted or referred to a 
      rehabilitation center for heroin (n=31) and synthetic cannabinoid users (n=30). 
      Heroin users and synthetic cannabinoid users were compared with healthy 
      volunteers (n=32) using two-dimensional (2D) speckle-tracking (ST) 
      echocardiography. RESULTS: No differences were found in the baseline 
      characteristics and 2D echocardiography values. The mean global longitudinal 
      strain value was -20.5%+/-2.4% for SCB users, -22.3%+/-2.4% for opioid users, and 
      -22.5%+/-2.2% for healthy volunteers (p=0.024). The mean apical 2-chamber (AP2C) 
      L-strain values were -20.1%+/-3.1%, -22.4%+/-3.0%, and -22.3%+/-2.8% for SCB users, 
      opioid users, and healthy volunteers, respectively (p=0.032). The mean apical 
      4-chamber (AP4C) L-strain values were -20.7%+/-2.5% for SCB users, -23.2%+/-3.2% for 
      opioid users, and -23.8%+/-3.1% for healthy volunteers (p<0.001). CONCLUSION: SCBs 
      are potential causes of subclinical left ventricular dysfunction.
FAU - Demirkiran, Aykut
AU  - Demirkiran A
AD  - Department of Cardiology, Tekirdag Corlu State Hospital; Tekirdag-Turkey. 
      aykut_wax@hotmail.com.
FAU - Albayrak, Neslihan
AU  - Albayrak N
FAU - Albayrak, Yakup
AU  - Albayrak Y
FAU - Zorkun, Cafer Sadik
AU  - Zorkun CS
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
RN  - 0 (Cannabinoids)
RN  - 70D95007SX (Heroin)
SB  - IM
CIN - Anatol J Cardiol. 2018 Oct;20(4):252. PMID: 30297586
MH  - Cannabinoids/*adverse effects/chemical synthesis
MH  - Case-Control Studies
MH  - Double-Blind Method
MH  - Echocardiography
MH  - Female
MH  - Heroin/*adverse effects
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Substance-Related Disorders/*diagnostic imaging
MH  - Ventricular Dysfunction, Left/*chemically induced/diagnostic imaging
MH  - Young Adult
PMC - PMC5998859
COIS- Conflict of interest: None declared.
EDAT- 2018/06/01 06:00
MHDA- 2019/05/24 06:00
PMCR- 2018/06/01
CRDT- 2018/06/01 06:00
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2019/05/24 06:00 [medline]
PHST- 2018/06/01 00:00 [pmc-release]
AID - AJC-19-388 [pii]
AID - 10.14744/AnatolJCardiol.2018.76429 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2018 Jun;19(6):388-393. doi: 
      10.14744/AnatolJCardiol.2018.76429.