PMID- 29849577
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2018
DP  - 2018
TI  - Region-Dependent Alterations in Cognitive Function and ERK1/2 Signaling in the 
      PFC in Rats after Social Defeat Stress.
PG  - 9870985
LID - 10.1155/2018/9870985 [doi]
LID - 9870985
AB  - Cognitive dysfunctions are highly comorbid with depression. Impairments of 
      cognitive flexibility, which are modulated by the monoaminergic system of the 
      prefrontal cortex (PFC), are increasingly recognized as an important component of 
      the pathophysiology and treatment of depression. However, the downstream 
      molecular mechanisms remain unclear. Using a classical model of depression, this 
      study investigated the effects of social defeat stress on emotional behaviors, on 
      cognitive flexibility in the attentional set-shifting task (AST), and on the 
      expression of extracellular signal-regulated kinase 1 and 2 (ERK1 and ERK2) and 
      their downstream signaling molecules cAMP-response element binding protein (CREB) 
      and brain-derived neurotrophic factor (BDNF) in two subregions of the PFC, the 
      medial prefrontal cortex (mPFC), and the orbitofrontal cortex (OFC). The results 
      showed that stress induced emotional and cognitive alterations associated with 
      depression, including a decreased sucrose intake ratio and impaired reversal 
      learning and set-shifting performance in the AST. Additionally, rats in the 
      stress group showed a significant decrease only in ERK2 signaling in the mPFC, 
      while more extensive decreases in both ERK1 signaling and ERK2 signaling were 
      observed in the OFC. Along with the decreased ERK signaling, compared to 
      controls, stressed rats showed downregulation of CREB phosphorylation and BDNF 
      expression in both the OFC and the mPFC. Further analysis showed that behavioral 
      changes were differentially correlated with several molecules in subregions of 
      the PFC. These results suggested that social defeat stress was an effective 
      animal model to induce both emotional and cognitive symptoms of depression and 
      that the dysfunction of ERK signaling activities in the PFC might be a potential 
      underlying biological mechanism.
FAU - Wang, Qiong
AU  - Wang Q
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China, 
      School of Education, Zhengzhou University, Zhengzhou, China.
AD  - The University of Chinese Academy of Sciences, Beijing, China.
FAU - Shao, Feng
AU  - Shao F
AUID- ORCID: 0000-0003-3662-4619
AD  - School of Psychological and Cognitive Sciences, Beijing Key Laboratory of 
      Behavior and Mental Health, Peking University, Beijing, China.
FAU - Wang, Weiwen
AU  - Wang W
AUID- ORCID: 0000-0001-9231-6106
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China, 
      School of Education, Zhengzhou University, Zhengzhou, China.
AD  - The University of Chinese Academy of Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180411
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Choice Behavior/physiology
MH  - Cognition/*physiology
MH  - Disease Models, Animal
MH  - MAP Kinase Signaling System/*physiology
MH  - Male
MH  - Phosphorylation
MH  - Prefrontal Cortex/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - *Social Dominance
MH  - Stress, Psychological/*metabolism
PMC - PMC5925180
EDAT- 2018/06/01 06:00
MHDA- 2018/12/12 06:00
PMCR- 2018/04/11
CRDT- 2018/06/01 06:00
PHST- 2018/01/13 00:00 [received]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/11 00:00 [pmc-release]
AID - 10.1155/2018/9870985 [doi]
PST - epublish
SO  - Neural Plast. 2018 Apr 11;2018:9870985. doi: 10.1155/2018/9870985. eCollection 
      2018.