PMID- 29849690
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2018
DP  - 2018
TI  - The Effect of Electroacupuncture versus Manual Acupuncture through the Expression 
      of TrkB/NF-kappaB in the Subgranular Zone of the Dentate Gyrus of 
      Telomerase-Deficient Mice.
PG  - 1013978
LID - 10.1155/2018/1013978 [doi]
LID - 1013978
AB  - Our previous study showed that the acupuncture stimulation on the acupoint 
      (ST-36) could activate the brain-derived neurotropic factor (BDNF) signaling 
      pathways in telomerase-deficient mice. Recently, we set out to investigate 
      whether the manual acupuncture (MA) or electroacupuncture (EA) displays a 
      therapeutic advantage on age-related deterioration of learning and memory. Both 
      telomerase-deficient mice (Terc(-/-) group, n = 24) and wild-type mice (WT group, 
      n = 24) were randomly assigned to 3 subgroups (CON, controls with no treatment; 
      MA, mice receiving manual acupuncture; EA, mice receiving electric acupuncture). 
      The mice were subjected to behavior test, and EA/MA were applied at bilateral 
      acupoints (ST36) 30 min daily for 7 successive days. The brain tissues were 
      collected after the last Morris water maze (MWM) test and were subjected to the 
      immunohistochemistry and western blot analysis. The MWM test showed that EA can 
      significantly increase the time in target quadrant (P </= 0.01) and frequency of 
      locating platform for Terc(-/-) mice (P </= 0.05), while nothing changed in WT 
      mice. Furthermore, western blotting and immunohistochemistry suggested that EA 
      could also specifically increase the expression of TrkB and NF-kappaB in Terc(-/-) 
      mice but not in wild-type mice (P </= 0.05). Meanwhile, the expression level and 
      ratio of ERK/p-ERK did not exhibit significant changes in each subgroup. These 
      results indicated that, compared with MA, the application of EA could 
      specifically ameliorate the spatial learning and memory capability for 
      telomerase-deficient mice through the activation of TrkB and NF-kappaB.
FAU - Lin, Dong
AU  - Lin D
AUID- ORCID: 0000-0002-2478-4431
AD  - College of Acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou, Fujian 350122, China.
FAU - Zhang, Jie
AU  - Zhang J
AUID- ORCID: 0000-0002-6393-5909
AD  - Department of Rehabilitation, People's Hospital Affiliated to Fujian University 
      of Traditional Chinese Medicine, Fuzhou, Fujian 350002, China.
FAU - Zhuang, Wanyu
AU  - Zhuang W
AUID- ORCID: 0000-0002-1842-7542
AD  - College of Acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou, Fujian 350122, China.
FAU - Yan, Xiaodan
AU  - Yan X
AUID- ORCID: 0000-0002-8222-6593
AD  - College of Integrated Traditional Chinese and Western Medicine, Fujian University 
      of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou, Fujian 350122, China.
FAU - Yang, Xiaoting
AU  - Yang X
AUID- ORCID: 0000-0002-9687-2123
AD  - College of Acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou, Fujian 350122, China.
FAU - Lin, Shen
AU  - Lin S
AUID- ORCID: 0000-0003-3901-9393
AD  - College of Acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou, Fujian 350122, China.
FAU - Lin, Lili
AU  - Lin L
AUID- ORCID: 0000-0002-5983-083X
AD  - College of Acupuncture, Fujian University of Traditional Chinese Medicine, Minhou 
      Shangjie, Fuzhou, Fujian 350122, China.
LA  - eng
PT  - Journal Article
DEP - 20180422
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5937603
EDAT- 2018/06/01 06:00
MHDA- 2018/06/01 06:01
PMCR- 2018/04/22
CRDT- 2018/06/01 06:00
PHST- 2017/12/21 00:00 [received]
PHST- 2018/03/07 00:00 [accepted]
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/06/01 06:01 [medline]
PHST- 2018/04/22 00:00 [pmc-release]
AID - 10.1155/2018/1013978 [doi]
PST - epublish
SO  - Evid Based Complement Alternat Med. 2018 Apr 22;2018:1013978. doi: 
      10.1155/2018/1013978. eCollection 2018.