PMID- 29849779
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 5
DP  - 2018 May
TI  - Relationship between depression and inflammatory factors and brain-derived 
      neurotrophic factor in patients with perimenopause syndrome.
PG  - 4436-4440
LID - 10.3892/etm.2018.5985 [doi]
AB  - The relationship of depression with levels of serum inflammatory factors and 
      brain-derived neurotrophic factor (BDNF) in patients with perimenopausal syndrome 
      was analyzed to investigate the predictive values of risk factors for depression 
      in patients with perimenopausal syndrome. A total of 73 patients with 
      perimenopausal syndrome were selected, and divided into the depression (n=30) and 
      non-depression (n=43) groups. Results showed that the self-rating anxiety scale 
      (SAS) and self-rating depression scale (SDS) scores in the depression group were 
      significantly higher than those in the non-depression group (P<0.05). The serum 
      BDNF level in the depression group was significantly lower than that in the 
      non-depression group (P<0.05). The levels of serum inflammatory factors, 
      including C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis 
      factor-alpha (TNF-alpha), in depression group were obviously higher than those in 
      non-depression group (P<0.05). The correlation analyses of serum inflammatory 
      factor and BDNF levels with depression showed that CRP and TNF-alpha were positively 
      correlated with SDS score, while BDNF level was negatively correlated with SDS 
      score. Logistic regression analyses revealed that menstrual status, chronic 
      diseases, serum inflammatory factors (CRP, IL-6 and TNF-alpha) and BDNF levels had 
      independent predictive values for depression in patients with perimenopausal 
      syndrome (P<0.05). In conclusion, levels of serum CRP, IL-6, TNF-alpha and BDNF can 
      be used as judgment indicators for the severity of depression.
FAU - Guo, Li
AU  - Guo L
AD  - Department of Gynaecology and Obstetrics, Affiliated Hospital of Inner Mongolia 
      Medical University, Hohhot, Inner Mongolia 010050, P.R. China.
FAU - Ren, Lidong
AU  - Ren L
AD  - Department of Breast, Thyroid, Hernia and Vascular Surgery, Inner Mongolia 
      People's Hospital, Hohhot, Inner Mongolia 010050, P.R. China.
FAU - Zhang, Caixia
AU  - Zhang C
AD  - Department of Gynaecology and Obstetrics, Affiliated Hospital of Inner Mongolia 
      Medical University, Hohhot, Inner Mongolia 010050, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180322
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5962862
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - depression
OT  - inflammatory factors
OT  - perimenopausal syndrome
EDAT- 2018/06/01 06:00
MHDA- 2018/06/01 06:01
PMCR- 2018/03/22
CRDT- 2018/06/01 06:00
PHST- 2017/12/15 00:00 [received]
PHST- 2018/03/01 00:00 [accepted]
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/06/01 06:01 [medline]
PHST- 2018/03/22 00:00 [pmc-release]
AID - ETM-0-0-5985 [pii]
AID - 10.3892/etm.2018.5985 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 May;15(5):4436-4440. doi: 10.3892/etm.2018.5985. Epub 2018 Mar 
      22.