PMID- 29850600
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20190723
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2018
DP  - 2018
TI  - Calcium Signaling in the Ventricular Myocardium of the Goto-Kakizaki Type 2 
      Diabetic Rat.
PG  - 2974304
LID - 10.1155/2018/2974304 [doi]
LID - 2974304
AB  - The association between diabetes mellitus (DM) and high mortality linked to 
      cardiovascular disease (CVD) is a major concern worldwide. Clinical and 
      preclinical studies have demonstrated a variety of diastolic and systolic 
      dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity 
      of abnormalities depending on the patients' age and duration of diabetes. The 
      cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not 
      well understood. The aim of this review is to evaluate our current understanding 
      of contractile dysfunction and disturbances of Ca(2+) transport in the 
      Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, 
      nonhypertensive genetic model of T2DM which is characterized by insulin 
      resistance, elevated blood glucose, alterations in blood lipid profile, and 
      cardiac dysfunction.
FAU - Al Kury, L
AU  - Al Kury L
AUID- ORCID: 0000-0002-8338-7655
AD  - College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE.
FAU - Smail, M
AU  - Smail M
AD  - Department of Physiology, College of Medicine & Health Sciences, UAE University, 
      Al Ain, UAE.
FAU - Qureshi, M A
AU  - Qureshi MA
AD  - Department of Physiology, College of Medicine & Health Sciences, UAE University, 
      Al Ain, UAE.
FAU - Sydorenko, V
AU  - Sydorenko V
AD  - Department of Cellular Membranology, Bogomoletz Institute of Physiology, Kiev, 
      Ukraine.
FAU - Shmygol, A
AU  - Shmygol A
AUID- ORCID: 0000-0001-7198-7920
AD  - Department of Physiology, College of Medicine & Health Sciences, UAE University, 
      Al Ain, UAE.
FAU - Oz, M
AU  - Oz M
AD  - Department of Basic Medical Sciences, College of Medicine, Qatar University, 
      Doha, Qatar.
FAU - Singh, J
AU  - Singh J
AUID- ORCID: 0000-0002-3200-3949
AD  - School of Forensic & Applied Sciences, University of Central Lancashire, Preston, 
      UK.
FAU - Howarth, F C
AU  - Howarth FC
AUID- ORCID: 0000-0002-0224-0556
AD  - Department of Physiology, College of Medicine & Health Sciences, UAE University, 
      Al Ain, UAE.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180410
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Calcium Signaling/*physiology
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Disease Models, Animal
MH  - Heart Ventricles/*metabolism
MH  - Myocardium/*metabolism
MH  - Myocytes, Cardiac/metabolism
MH  - Rats
PMC - PMC5914098
EDAT- 2018/06/01 06:00
MHDA- 2018/10/12 06:00
PMCR- 2018/04/10
CRDT- 2018/06/01 06:00
PHST- 2017/10/18 00:00 [received]
PHST- 2018/01/16 00:00 [revised]
PHST- 2018/03/08 00:00 [accepted]
PHST- 2018/06/01 06:00 [entrez]
PHST- 2018/06/01 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2018/04/10 00:00 [pmc-release]
AID - 10.1155/2018/2974304 [doi]
PST - epublish
SO  - J Diabetes Res. 2018 Apr 10;2018:2974304. doi: 10.1155/2018/2974304. eCollection 
      2018.